北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Is It Necessary to Combine Detection of Anticitrullinated Protein Antibodies in the Diagnosis of Rheumatoid Arthritis?
作者: Zhao, Jinxia2; Liu, Xangyuan2; Wang, Zhimin1; Liu, Rui2; Li, Zhanguo1
关键词: ANTICITRULLINATED PROTEIN ANTIBODIES ; ANTIKERATIN ANTIBODIES ; ANTIPERINUCLEAR FACTOR ; RHEUMATOID ARTHRITIS
刊名: JOURNAL OF RHEUMATOLOGY
发表日期: 2010-12-01
DOI: 10.3899/jrheum.100399
卷: 37, 期:12, 页:2462-2465
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: CYCLIC CITRULLINATED PEPTIDE ; ANTIPERINUCLEAR FACTOR ; REVISED CRITERIA ; AUTOANTIBODIES ; CLASSIFICATION
英文摘要:

Objective. Antibodies against citrulline-containing epitopes, such as antiperinuclear factor (APF), antikeratin antibodies (AKA), antifilaggrin antibodies, and anticyclic citrullinated peptide (anti-CCP) antibodies, are specific in rheumatoid arthritis (RA). Detection of APF, AKA, and anti-CCP has been widely used in clinical practice. However, studies on combined detection of these anticitrullinated protein antibodies (ACPA) in the significance of diagnosing RA have been limited. We aimed to detect APF, AKA, and anti-CCP antibodies and to evaluate the significance of combined detection of these ACPA in RA.

Methods. A total of 551 patients with arthritic disorders, 304 with RA and 247 with other rheumatic diseases, were selected at the Department of Rheumatology and Immunology during the past 2 years. AKA and APF were tested by indirect immunofluorescence assay. Anti-CCP was detected using the second-generation ELISA kit.

Results. The sensitivities of anti-CCP, AKA, and APF tests for RA were 76.2%, 43.4%, and 34.5%, respectively, while the specificities were 96.0%, 98.4%, and 99.6%. The combination of anti-CCP, AKA, and APF positivity had the highest specificity (100%), but it yielded a low sensitivity (28.3%). When 2 of the 3 ACPA were positive, the sensitivity and specificity were 48.4% and 99.2%, respectively. When either anti-CCP or AKA or APF was positive, sensitivity increased to 77.3%, but specificity decreased to 94.7%.

Conclusion. Anti-CCP was the most valuable marker in the diagnosis of RA, among the 3 ACPA. Combined detection of anti-CCP, AKA, and APF did not increase the diagnostic capability for RA. (First Release Oct 152010; J Rheumatol 2010;37:2462-5; doi:10.3899/jrheum.100399)

语种: 英语
所属项目编号: 2008BAI59B01 ; 30772012
项目资助者: Key projects in the national science and technology pillar ; National Natural Science Foundation of China
WOS记录号: WOS:000285272600004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68253
Appears in Collections:北京大学第二临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Dept Rheumatol & Immunol, Peoples Hosp, Beijing 100871, Peoples R China
2.Peking Univ, Dept Rheumatol & Immunol, Hosp 3, Beijing 100871, Peoples R China

Recommended Citation:
Zhao, Jinxia,Liu, Xangyuan,Wang, Zhimin,et al. Is It Necessary to Combine Detection of Anticitrullinated Protein Antibodies in the Diagnosis of Rheumatoid Arthritis?[J]. JOURNAL OF RHEUMATOLOGY,2010,37(12):2462-2465.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhao, Jinxia]'s Articles
[Liu, Xangyuan]'s Articles
[Wang, Zhimin]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhao, Jinxia]‘s Articles
[Liu, Xangyuan]‘s Articles
[Wang, Zhimin]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace