IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Is It Necessary to Combine Detection of Anticitrullinated Protein Antibodies in the Diagnosis of Rheumatoid Arthritis?
Zhao, Jinxia2; Liu, Xangyuan2; Wang, Zhimin1; Liu, Rui2; Li, Zhanguo1
关键词ANTICITRULLINATED PROTEIN ANTIBODIES ANTIKERATIN ANTIBODIES ANTIPERINUCLEAR FACTOR RHEUMATOID ARTHRITIS
刊名JOURNAL OF RHEUMATOLOGY
2010-12-01
DOI10.3899/jrheum.100399
37期:12页:2462-2465
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]CYCLIC CITRULLINATED PEPTIDE ; ANTIPERINUCLEAR FACTOR ; REVISED CRITERIA ; AUTOANTIBODIES ; CLASSIFICATION
英文摘要

Objective. Antibodies against citrulline-containing epitopes, such as antiperinuclear factor (APF), antikeratin antibodies (AKA), antifilaggrin antibodies, and anticyclic citrullinated peptide (anti-CCP) antibodies, are specific in rheumatoid arthritis (RA). Detection of APF, AKA, and anti-CCP has been widely used in clinical practice. However, studies on combined detection of these anticitrullinated protein antibodies (ACPA) in the significance of diagnosing RA have been limited. We aimed to detect APF, AKA, and anti-CCP antibodies and to evaluate the significance of combined detection of these ACPA in RA.

Methods. A total of 551 patients with arthritic disorders, 304 with RA and 247 with other rheumatic diseases, were selected at the Department of Rheumatology and Immunology during the past 2 years. AKA and APF were tested by indirect immunofluorescence assay. Anti-CCP was detected using the second-generation ELISA kit.

Results. The sensitivities of anti-CCP, AKA, and APF tests for RA were 76.2%, 43.4%, and 34.5%, respectively, while the specificities were 96.0%, 98.4%, and 99.6%. The combination of anti-CCP, AKA, and APF positivity had the highest specificity (100%), but it yielded a low sensitivity (28.3%). When 2 of the 3 ACPA were positive, the sensitivity and specificity were 48.4% and 99.2%, respectively. When either anti-CCP or AKA or APF was positive, sensitivity increased to 77.3%, but specificity decreased to 94.7%.

Conclusion. Anti-CCP was the most valuable marker in the diagnosis of RA, among the 3 ACPA. Combined detection of anti-CCP, AKA, and APF did not increase the diagnostic capability for RA. (First Release Oct 152010; J Rheumatol 2010;37:2462-5; doi:10.3899/jrheum.100399)

语种英语
WOS记录号WOS:000285272600004
项目编号2008BAI59B01 ; 30772012
资助机构Key projects in the national science and technology pillar ; National Natural Science Foundation of China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68253
专题北京大学第二临床医学院
北京大学第二临床医学院_风湿免疫科
北京大学第三临床医学院_风湿免疫科
北京大学口腔医学院_综合治疗科
作者单位1.Peking Univ, Dept Rheumatol & Immunol, Peoples Hosp, Beijing 100871, Peoples R China
2.Peking Univ, Dept Rheumatol & Immunol, Hosp 3, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Jinxia,Liu, Xangyuan,Wang, Zhimin,et al. Is It Necessary to Combine Detection of Anticitrullinated Protein Antibodies in the Diagnosis of Rheumatoid Arthritis?[J]. JOURNAL OF RHEUMATOLOGY,2010,37(12):2462-2465.
APA Zhao, Jinxia,Liu, Xangyuan,Wang, Zhimin,Liu, Rui,&Li, Zhanguo.(2010).Is It Necessary to Combine Detection of Anticitrullinated Protein Antibodies in the Diagnosis of Rheumatoid Arthritis?.JOURNAL OF RHEUMATOLOGY,37(12),2462-2465.
MLA Zhao, Jinxia,et al."Is It Necessary to Combine Detection of Anticitrullinated Protein Antibodies in the Diagnosis of Rheumatoid Arthritis?".JOURNAL OF RHEUMATOLOGY 37.12(2010):2462-2465.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhao, Jinxia]的文章
[Liu, Xangyuan]的文章
[Wang, Zhimin]的文章
百度学术
百度学术中相似的文章
[Zhao, Jinxia]的文章
[Liu, Xangyuan]的文章
[Wang, Zhimin]的文章
必应学术
必应学术中相似的文章
[Zhao, Jinxia]的文章
[Liu, Xangyuan]的文章
[Wang, Zhimin]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。