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学科主题: 临床医学
题名:
Efficacy and safety of insulin treatment in type 2 diabetes using a new index called glucose safety control index
作者: Cai Xiao-ling; Luo Ying-ying; Han Xue-yao; Ji Li-nong
关键词: hemoglobin A1c ; hypoglycemia ; type 2 diabetes
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2013-11-05
DOI: 10.3760/cma.j.issn.0366-6999.20131186
卷: 126, 期:21, 页:4166-4174
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: ONCE-DAILY INSULIN ; PROTAMINE HAGEDORN INSULIN ; ORAL ANTIDIABETIC AGENTS ; TWICE-DAILY INJECTIONS ; BEDTIME NPH INSULIN ; BASAL-BOLUS THERAPY ; TO-TARGET TRIAL ; PREMIXED INSULIN ; OPEN-LABEL ; PARALLEL-GROUP
英文摘要:

Objective To recommend an index named glucose safety control index (GSCI) to evaluate the efficacy and safety for insulin regimens.

Data sources We searched databases for primary studies published in English. The main search concepts were type 2 diabetes, insulin treatment, premixed insulin, premixed insulin analogs, basal muslin, basal muslin analogs, bolus insulin, bolus insulin analogs, safety and efficacy.

Study selection Studies were eligible for inclusion if they met all of the following criteria: (1) type 2 diabetic patients aged >18 years were included; (2) random control studies with at least 12 weeks of follow-up; (3) different insulin regimens were evaluated.

Results When long-acting basal insulin therapy compared with neutral protamine Hagedorn (NPH) insulin therapy, the proportion of GSCI(%A1c) ratio more than 1 was 100%, the proportion of GSCI(Delta A1c) ratio more than 1 was 94.44%. When premixed insulin therapy compared with oral hypoglycemic agents plus basal insulin therapy, the proportion of GSCI(%A1c) ratio more than 1 was 45.5%, the proportion of GSCI(Delta A1c) ratio more than 1 was 38.9%. When premixed insulin therapy compared with oral hypoglycemic agents, the proportion of GSCI(%A1c) ratio less than 1 was 100%, the proportion of GSCI(Delta A1c) ratio more than 1 was 50%. When premixed insulin therapy compared with basal-bolus insulin therapy, the proportion of GSCI(%A1c) ratio more than 1 was 37.5%, the proportion of GSCI(Delta A1c) ratio more than 1 was 50%.

Conclusion According to the GSCI ratio, long-acting basal insulin therapy tended to be superior to NPH therapy, oral hypoglycemic agents plus basal insulin therapy tended to be superior to premixed insulin therapy, noninsulin antidiabetic agents and premixed insulin therapy was comparable, and basal-bolus insulin therapy tended to be superior to premixed insulin therapy in type 2 diabetes.

语种: 英语
所属项目编号: 81000334
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000327916400029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68254
Appears in Collections:北京大学第二临床医学院_内分泌科_期刊论文

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作者单位: Peking Univ, Ctr Diabet, Peking Univ Peoples Hosp, Dept Endocrinol & Metab, Beijing 100044, Peoples R China

Recommended Citation:
Cai Xiao-ling,Luo Ying-ying,Han Xue-yao,et al. Efficacy and safety of insulin treatment in type 2 diabetes using a new index called glucose safety control index[J]. CHINESE MEDICAL JOURNAL,2013,126(21):4166-4174.
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