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学科主题临床医学
Efficacy and safety of insulin treatment in type 2 diabetes using a new index called glucose safety control index
Cai Xiao-ling; Luo Ying-ying; Han Xue-yao; Ji Li-nong
关键词hemoglobin A1c hypoglycemia type 2 diabetes
刊名CHINESE MEDICAL JOURNAL
2013-11-05
DOI10.3760/cma.j.issn.0366-6999.20131186
126期:21页:4166-4174
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]ONCE-DAILY INSULIN ; PROTAMINE HAGEDORN INSULIN ; ORAL ANTIDIABETIC AGENTS ; TWICE-DAILY INJECTIONS ; BEDTIME NPH INSULIN ; BASAL-BOLUS THERAPY ; TO-TARGET TRIAL ; PREMIXED INSULIN ; OPEN-LABEL ; PARALLEL-GROUP
英文摘要

Objective To recommend an index named glucose safety control index (GSCI) to evaluate the efficacy and safety for insulin regimens.

Data sources We searched databases for primary studies published in English. The main search concepts were type 2 diabetes, insulin treatment, premixed insulin, premixed insulin analogs, basal muslin, basal muslin analogs, bolus insulin, bolus insulin analogs, safety and efficacy.

Study selection Studies were eligible for inclusion if they met all of the following criteria: (1) type 2 diabetic patients aged >18 years were included; (2) random control studies with at least 12 weeks of follow-up; (3) different insulin regimens were evaluated.

Results When long-acting basal insulin therapy compared with neutral protamine Hagedorn (NPH) insulin therapy, the proportion of GSCI(%A1c) ratio more than 1 was 100%, the proportion of GSCI(Delta A1c) ratio more than 1 was 94.44%. When premixed insulin therapy compared with oral hypoglycemic agents plus basal insulin therapy, the proportion of GSCI(%A1c) ratio more than 1 was 45.5%, the proportion of GSCI(Delta A1c) ratio more than 1 was 38.9%. When premixed insulin therapy compared with oral hypoglycemic agents, the proportion of GSCI(%A1c) ratio less than 1 was 100%, the proportion of GSCI(Delta A1c) ratio more than 1 was 50%. When premixed insulin therapy compared with basal-bolus insulin therapy, the proportion of GSCI(%A1c) ratio more than 1 was 37.5%, the proportion of GSCI(Delta A1c) ratio more than 1 was 50%.

Conclusion According to the GSCI ratio, long-acting basal insulin therapy tended to be superior to NPH therapy, oral hypoglycemic agents plus basal insulin therapy tended to be superior to premixed insulin therapy, noninsulin antidiabetic agents and premixed insulin therapy was comparable, and basal-bolus insulin therapy tended to be superior to premixed insulin therapy in type 2 diabetes.

语种英语
WOS记录号WOS:000327916400029
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68254
专题北京大学第二临床医学院_内分泌科
作者单位Peking Univ, Ctr Diabet, Peking Univ Peoples Hosp, Dept Endocrinol & Metab, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Cai Xiao-ling,Luo Ying-ying,Han Xue-yao,et al. Efficacy and safety of insulin treatment in type 2 diabetes using a new index called glucose safety control index[J]. CHINESE MEDICAL JOURNAL,2013,126(21):4166-4174.
APA Cai Xiao-ling,Luo Ying-ying,Han Xue-yao,&Ji Li-nong.(2013).Efficacy and safety of insulin treatment in type 2 diabetes using a new index called glucose safety control index.CHINESE MEDICAL JOURNAL,126(21),4166-4174.
MLA Cai Xiao-ling,et al."Efficacy and safety of insulin treatment in type 2 diabetes using a new index called glucose safety control index".CHINESE MEDICAL JOURNAL 126.21(2013):4166-4174.
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