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Effects of dust storm PM2.5 on cell proliferation and cell cycle in human lung fibroblasts
Deng, Furong; Guo, Xinbiao; Liu, Hong; Fang, Xin; Yang, Minjuan; Chen, Wei
关键词dust storm particulate matter lung cells proliferation
刊名TOXICOLOGY IN VITRO
2007-06-01
DOI10.1016/j.tiv.2006.12.013
21期:4页:632-638
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Toxicology
研究领域[WOS]Toxicology
关键词[WOS]PARTICULATE AIR-POLLUTION ; EPITHELIAL-CELLS ; DAILY MORTALITY ; FINE PARTICLES ; AMBIENT AIR ; DNA-DAMAGE ; EVENTS ; TAIWAN ; MATTER ; TAIPEI
英文摘要

Reports on the effects of PM2.5 from dust storm on lung cells are limited. We compared the effects of PM2.5 collected in dust storm days (dust storm PM2.5) with that in sunshiny and non-dust storm days (normal PM2.5) on cell proliferation and cell cycle in human lung fibroblasts. Our results showed that both dust storm and normal PM2.5 had biphasic effects on cell proliferation, namely, stimulated cell proliferation at lower concentrations while inhibited it at higher concentrations. On the contrary, the organic and inorganic extracts from dust storm and normal PM2.5 significantly inhibited the proliferation in human lung fibroblasts at the concentrations corresponding to their mass contents in PM2.5 samples. The flow cytometry showed that the number of cells in G2/M phase increased significantly after treatment with the dust storm and normal PM2.5. The inorganic and organic extracts from PM2.5, however, induced cell arrest in S phase and G0/G1 phase, respectively. It seems that the biphasic effects of both dust storm and normal PM2.5 on cell proliferation may not be related to their inorganic or organic extractable components. (C) 2007 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000247131600012
Citation statistics
Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68259
Collection北京大学公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100083, Peoples R China
2.Inner Mongolia Med Univ, Dept Publ Hlth, Hohhot, Peoples R China
Recommended Citation
GB/T 7714
Deng, Furong,Guo, Xinbiao,Liu, Hong,et al. Effects of dust storm PM2.5 on cell proliferation and cell cycle in human lung fibroblasts[J]. TOXICOLOGY IN VITRO,2007,21(4):632-638.
APA Deng, Furong,Guo, Xinbiao,Liu, Hong,Fang, Xin,Yang, Minjuan,&Chen, Wei.(2007).Effects of dust storm PM2.5 on cell proliferation and cell cycle in human lung fibroblasts.TOXICOLOGY IN VITRO,21(4),632-638.
MLA Deng, Furong,et al."Effects of dust storm PM2.5 on cell proliferation and cell cycle in human lung fibroblasts".TOXICOLOGY IN VITRO 21.4(2007):632-638.
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