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学科主题: 公共卫生
题名:
Effects of dust storm PM2.5 on cell proliferation and cell cycle in human lung fibroblasts
作者: Deng, Furong; Guo, Xinbiao; Liu, Hong; Fang, Xin; Yang, Minjuan; Chen, Wei
关键词: dust storm ; particulate matter ; lung cells ; proliferation
刊名: TOXICOLOGY IN VITRO
发表日期: 2007-06-01
DOI: 10.1016/j.tiv.2006.12.013
卷: 21, 期:4, 页:632-638
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Toxicology
研究领域[WOS]: Toxicology
关键词[WOS]: PARTICULATE AIR-POLLUTION ; EPITHELIAL-CELLS ; DAILY MORTALITY ; FINE PARTICLES ; AMBIENT AIR ; DNA-DAMAGE ; EVENTS ; TAIWAN ; MATTER ; TAIPEI
英文摘要:

Reports on the effects of PM2.5 from dust storm on lung cells are limited. We compared the effects of PM2.5 collected in dust storm days (dust storm PM2.5) with that in sunshiny and non-dust storm days (normal PM2.5) on cell proliferation and cell cycle in human lung fibroblasts. Our results showed that both dust storm and normal PM2.5 had biphasic effects on cell proliferation, namely, stimulated cell proliferation at lower concentrations while inhibited it at higher concentrations. On the contrary, the organic and inorganic extracts from dust storm and normal PM2.5 significantly inhibited the proliferation in human lung fibroblasts at the concentrations corresponding to their mass contents in PM2.5 samples. The flow cytometry showed that the number of cells in G2/M phase increased significantly after treatment with the dust storm and normal PM2.5. The inorganic and organic extracts from PM2.5, however, induced cell arrest in S phase and G0/G1 phase, respectively. It seems that the biphasic effects of both dust storm and normal PM2.5 on cell proliferation may not be related to their inorganic or organic extractable components. (C) 2007 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000247131600012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68259
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100083, Peoples R China
2.Inner Mongolia Med Univ, Dept Publ Hlth, Hohhot, Peoples R China

Recommended Citation:
Deng, Furong,Guo, Xinbiao,Liu, Hong,et al. Effects of dust storm PM2.5 on cell proliferation and cell cycle in human lung fibroblasts[J]. TOXICOLOGY IN VITRO,2007,21(4):632-638.
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