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学科主题: 临床医学
题名:
Hyperhomocysteinemia Accelerates Collagen Accumulation in the Adventitia of Balloon-Injured Rat Carotid Arteries via Angiotensin II Type 1 Receptor
作者: Yao, Dan; Sun, Ning-Ling
关键词: hyperhomocysteinemia ; homocysteine ; adverntitia ; collagen ; Ang II type 1 receptor
刊名: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
发表日期: 2014-11-01
DOI: 10.3390/ijms151119487
卷: 15, 期:11, 页:19487-19498
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]: CORONARY ANGIOPLASTY ; PLASMA HOMOCYSTEINE ; VASCULAR-DISEASE ; RISK-FACTOR ; RESTENOSIS ; FIBROBLASTS ; MODEL ; ATHEROSCLEROSIS ; PROLIFERATION ; INFLAMMATION
英文摘要:

Recent studies suggest that hyperhomocysteinemia (HHcy) increases collagen type I accumulation in rat vascular adventitia after balloon injury and that Angiotensin II (Ang II) induces collagen synthesis in vascular adventitial fibroblasts. Reports also indicate that Ang II type1 receptor (AT(1)R) activation, mediated by homocysteine (Hcy) may contribute to collagen type 1 expression in mouse aortic endothelial cells. However, little is known about the possible mechanisms behind the relationship between Hcy and AT(1)R in adventitial remodeling. Thus, we investigated whether HHcy induces collagen accumulation via activation of AT(1)R in the adventitia. Male Sprague-Dawley (SD) rats were randomly divided into a control group and a 1% L-methionine-induced HHcy group. Balloon injury was performed after 12 experimental weeks and animals were sacrificed at 7, 14, and 28 days after injury. Collagen deposition and AT(1)R expression was measured with Western blot. Serum Hcy, adventitial collagen, and AT(1)R levels were higher in the HHcy group compared with the control group. Hcy time-dependently induced collagen type 1 and AT(1)R expression, with the highest induction observed at 48 h. Also, we observed that the AT(1)R blocker, valsartan, attenuated collagen type 1 and AT(1)R expression. HHcy exacerbates adventitial remodeling after balloon injury, and the underling mechanisms may be related to AT(1)R activity.

语种: 英语
WOS记录号: WOS:000345529200012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68260
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China

Recommended Citation:
Yao, Dan,Sun, Ning-Ling. Hyperhomocysteinemia Accelerates Collagen Accumulation in the Adventitia of Balloon-Injured Rat Carotid Arteries via Angiotensin II Type 1 Receptor[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2014,15(11):19487-19498.
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