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学科主题: 临床医学
题名:
Progenitor gene DLK1 might be an independent prognostic factor of liver cancer
作者: Jin, Zhong-hui1; Yang, Ren-jie1; Dong, Bin2; Xing, Bao-cai3
关键词: DLK1 ; liver cancer ; progenitor ; prognostic
刊名: EXPERT OPINION ON BIOLOGICAL THERAPY
发表日期: 2008-04-01
DOI: 10.1517/14712598.8.4.371
卷: 8, 期:4, 页:371-377
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]: Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]: HUMAN HEPATOCELLULAR-CARCINOMA ; CELL PROGENITORS ; MOUSE EMBRYO ; OVAL CELLS ; EXPRESSION ; HEPATOBLASTS ; REPOPULATION ; LINEAGES ; GTL2
英文摘要:

Background: Delta-like 1 homolog (DLK1) is a marker for progenitor cells of the liver. The gene encoding DLK1 is expressed early during embryonic development but, importantly, it is also expressed in some human liver cancers. However, the prognostic value of the DLK1 gene has not been investigated. Objectives: To examine the association between the DLK1 gene and survival time and whether high levels of expression of DLK1 are a prognostic factor for liver cancer. Methods: We evaluated 60 cases of primary liver cancer, and investigated the link between the expression of DLK1 and patient survival. Clinical characteristics of the cases used for our study, such as tumor size, differentiation and staging, are statistically evenly distributed. Using RT-PCR, western blotting and immunohistochemistry, we analyzed the expression of DLK1 in the tumor samples and evaluated the results statistically. Results: DLK1 was expressed in 22 of the 60 cases (36.7%), and analysis of the survival of the patients revealed that DLK1-positive patients had a shorter survival time than DLK1-negative patients. Cox regression analysis also showed that DLK1 is a risk factor. However, DLK1 expression does not seem to correlate with other classic prognostic factors such as alpha-fetoprotein (AFP), tumor-node-metastasis (TNM) and vascular invasion, which implies that it is an independent prognostic factor.

语种: 英语
WOS记录号: WOS:000255065200001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68261
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Intervant Therapy, Beijing 100036, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Ctr Lab, Beijing 100036, Peoples R China
3.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Surg, Beijing 100036, Peoples R China

Recommended Citation:
Jin, Zhong-hui,Yang, Ren-jie,Dong, Bin,et al. Progenitor gene DLK1 might be an independent prognostic factor of liver cancer[J]. EXPERT OPINION ON BIOLOGICAL THERAPY,2008,8(4):371-377.
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