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学科主题: 药物依赖
题名:
Valproate prevents the induction, but not the expression of morphine sensitization in mice
作者: Li, JX; Zhang, Q; Liang, JH
关键词: valproate ; behavioral sensitization ; morphine ; mice
刊名: BEHAVIOURAL BRAIN RESEARCH
发表日期: 2004-07-09
DOI: 10.1016/j.bbr.2003.10.006
卷: 152, 期:2, 页:251-257
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]: PROTEIN-KINASE-C ; EXCITATORY AMINO-ACIDS ; A10 DOPAMINE NEURONS ; BEHAVIORAL SENSITIZATION ; LOCOMOTOR-ACTIVITY ; RECEPTOR ANTAGONISTS ; AMBULATORY ACTIVITY ; REVERSE TOLERANCE ; GABAERGIC DRUGS ; IN-VITRO
英文摘要:

Repetitive exposure to opioids elicits sensitization to its locomotor stimulating effects. Several lines of evidence have shown that the central GABAergic system is involved in behavioral sensitization induced by morphine. Valproate, a clinically widely used anticonvulsant and mood stabilizer, can mainly inhibit gamma-aminobutyric acid (GABA) transaminase and activate glutamic acid decarboxylase, which result in decrease in the degradation and increase in the synthesis of GABA, and then the elevation of extracellular GABA in the central nervous system. However, the effects of valproate on behavioral sensitization to morphine have not been documented. Herein, we investigated the effects of valproate on the induction and the expression of behavioral sensitization to morphine. Mice treated daily for 7 days with 10 mg/kg morphine and challenged with the same dose after 7 days of washout showed increased locomotor activity. Co-administration of valproate (37.5, 75, 150 mg/kg, intraperitoneal (i.p.)), at doses that did not affect the spontaneous activity, 30 min prior to morphine dose-dependently inhibited the induction of morphine sensitization. However, neither single nor multiple administration (37.5, 75, 150 mg/kg x 7 injections) of valproate had any effect on the expression of morphine sensitization once it developed. Our results indicated that GABA plays an important role in the induction, but not in the expression of morphine sensitization in mice. (C) 2003 Published by Elsevier B.V.

语种: 英语
WOS记录号: WOS:000222734700009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68264
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100083, Peoples R China

Recommended Citation:
Li, JX,Zhang, Q,Liang, JH. Valproate prevents the induction, but not the expression of morphine sensitization in mice[J]. BEHAVIOURAL BRAIN RESEARCH,2004,152(2):251-257.
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