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学科主题: 临床医学
题名:
MORPHOLOGIC AND FUNCTIONAL EVALUATION BEFORE AND AFTER SUCCESSFUL MACULAR HOLE SURGERY USING SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY COMBINED WITH MICROPERIMETRY
作者: Chen, Wei-Chih1,2; Wang, Yu3; Li, Xiao-Xin1,2
关键词: microperimetry ; macular sensitivity ; idiopathic macular hole ; spectral-domain optical coherence tomography
刊名: RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
发表日期: 2012-10-01
DOI: 10.1097/IAE.0b013e318242b81a
卷: 32, 期:9, 页:1733-1742
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: SCANNING LASER OPHTHALMOSCOPE ; PHOTORECEPTOR OUTER SEGMENT ; VISUAL-ACUITY ; EPIRETINAL MEMBRANES ; FUNDUS PERIMETRY ; CLOSURE ; OUTCOMES ; IMAGES ; SENSITIVITY ; DISRUPTION
英文摘要:

Purpose: To evaluate photoreceptor inner/outer segment (IS/OS) defects, best-corrected visual acuity (BCVA), macular sensitivity, and fixation stability to correlate morphologic changes with visual functional outcomes at different stages after macular hole surgery using spectral-domain optical coherence tomography combined with microperimetry.

Methods: This study was an interventional, retrospective case series. Sixteen eyes of 16 patients with successfully operated idiopathic full-thickness macular holes were included in this study. The IS/OS defect maximal diameter and area, BCVA, central macular sensitivity, mean macular sensitivity, and fixation stability were measured using spectral-domain optical coherence tomography combined with microperimetry, preoperatively, and with a follow-up of 3 months postoperatively.

Results: Both the IS/OS defect diameter and area improved after successful macular hole surgery (P < 0.001; P < 0.001). The BCVA, central macular sensitivity, mean macular sensitivity, and fixation stability of the central 2 degrees also improved (P = 0.001; P = 0.004; P = 0.036; P = 0.031). Stable BCVA improvement was achieved as early as 1-month postoperation despite continuous repair of the IS/OS junction defect diameter and area and improvement in fixation and macular sensitivity within the first 3 months after surgery. The postoperative central macular sensitivity and mean macular sensitivity negatively correlated with preoperative linear IS/OS junction defect diameter (P = 0.033; P = 0.006) and the defect area (P < 0.001; P = 0.002). However, the postoperative BCVA and the improvement in BCVA, macular sensitivity, and fixation stability were not correlated with preoperative IS/OS defect diameter or area.

Conclusion: Continuous anatomical and functional improvements can be observed after successful microinvasive macular hole surgery. The preoperative extent of the IS/OS junction defect is of good predictive value for postoperative macular sensitivity. However, the factors that influence BCVA are multiple. Prediction of BCVA based on a single anatomical parameter or assessment of macular function only based on BCVA should be avoided. RETINA 32:1733-1742, 2012

语种: 英语
WOS记录号: WOS:000309217800005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68271
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: 1.Peking Univ Peoples Hosp, Dept Ophthalmol, Beijing 10044, Peoples R China
2.Minist Educ, Key Lab Vis Loss & Restorat, Beijing, Peoples R China
3.Tianjin Med Univ, Ctr Eye, Tianjin, Peoples R China

Recommended Citation:
Chen, Wei-Chih,Wang, Yu,Li, Xiao-Xin. MORPHOLOGIC AND FUNCTIONAL EVALUATION BEFORE AND AFTER SUCCESSFUL MACULAR HOLE SURGERY USING SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY COMBINED WITH MICROPERIMETRY[J]. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES,2012,32(9):1733-1742.
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