IR@PKUHSC  > 北京大学第三临床医学院  > 神经内科
学科主题临床医学
Serum level of homocysteine is correlated to carotid artery atherosclerosis in Chinese with ischemic stroke
Wang, HL; Fan, DS; Zhang, H; Fu, Y; Zhang, J; Shen, Y
关键词carotid artery diseases homocysteine folic acid vitamin B-12
刊名NEUROLOGICAL RESEARCH
2006
DOI10.1179/016164106X91834
28期:1页:25-30
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]INTIMA-MEDIA THICKNESS ; METHYLENETETRAHYDROFOLATE REDUCTASE ; PLASMA HOMOCYST(E)INE ; CEREBROVASCULAR-DISEASE ; ASYMPTOMATIC ADULTS ; CEREBRAL INFARCTION ; VASCULAR-DISEASE ; C677T MUTATION ; RISK ; ASSOCIATION
英文摘要

Objectives: To investigate the relationship between serum level of homocysteine (Hcy) and carotid artery atheroscleosis (CAA).

Methods: Both sides of the common carotid artery and internal carotid artery in 126 Chinese patients with ischemic stroke were measured by B-mode ultrasound. The patients were divided into groups: normal, A, B, C and D according to the severity of CAAs. With fasting serum, Hcy as well as folate, vitamin B-12 and lipids were detected. The mean +/- SD age was 64 +/- 13 years ( range 39 - 87 years).

Results: In a logistic regression model, the Hcy concentrations were associated with an elevated risk of CAAs independent of all traditional risk factors, and when CAAs became severer, the serum Hcy was higher. The levels of the normal group and A, B, C, D groups were 13.22 +/- 6.15 mu mol/l, 16.29 +/- 9.81 mu mol/l, 19.49 +/- 11.16 mu mol/l, 27.21 +/- 17.47 mu mol/l, and 24.14 +/- 8.64 mu mol/l, respectively. Rank test showed a significant difference between normal and other groups (p < 0.05). The levels of folate and vitamin B-12 were negatively correlated with the Hcy concentrations. Spearman correlation coefficient were -0.23 and -0.42 (p < 0.05).

Conclusions: Hyperhomocysteinaemia is an independent risk factor of CAAs and the degree of CAAs is highly correlated with the level of Hcy in serum. The causes of hyperhomocysteinemia may be the result from the decrease in folate and vitamin B-12. Clinical trials are now required to evaluate the effect of treatment with these vitamins on the primary and secondary prevention of cerebral vascular diseases.

语种英语
WOS记录号WOS:000235151100005
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68294
专题北京大学第三临床医学院_神经内科
作者单位Peking Univ, Hosp 3, Dept Neurol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Wang, HL,Fan, DS,Zhang, H,et al. Serum level of homocysteine is correlated to carotid artery atherosclerosis in Chinese with ischemic stroke[J]. NEUROLOGICAL RESEARCH,2006,28(1):25-30.
APA Wang, HL,Fan, DS,Zhang, H,Fu, Y,Zhang, J,&Shen, Y.(2006).Serum level of homocysteine is correlated to carotid artery atherosclerosis in Chinese with ischemic stroke.NEUROLOGICAL RESEARCH,28(1),25-30.
MLA Wang, HL,et al."Serum level of homocysteine is correlated to carotid artery atherosclerosis in Chinese with ischemic stroke".NEUROLOGICAL RESEARCH 28.1(2006):25-30.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, HL]的文章
[Fan, DS]的文章
[Zhang, H]的文章
百度学术
百度学术中相似的文章
[Wang, HL]的文章
[Fan, DS]的文章
[Zhang, H]的文章
必应学术
必应学术中相似的文章
[Wang, HL]的文章
[Fan, DS]的文章
[Zhang, H]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。