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学科主题: 临床医学
题名:
Serum level of homocysteine is correlated to carotid artery atherosclerosis in Chinese with ischemic stroke
作者: Wang, HL; Fan, DS; Zhang, H; Fu, Y; Zhang, J; Shen, Y
关键词: carotid artery diseases ; homocysteine ; folic acid ; vitamin B-12
刊名: NEUROLOGICAL RESEARCH
发表日期: 2006
DOI: 10.1179/016164106X91834
卷: 28, 期:1, 页:25-30
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: INTIMA-MEDIA THICKNESS ; METHYLENETETRAHYDROFOLATE REDUCTASE ; PLASMA HOMOCYST(E)INE ; CEREBROVASCULAR-DISEASE ; ASYMPTOMATIC ADULTS ; CEREBRAL INFARCTION ; VASCULAR-DISEASE ; C677T MUTATION ; RISK ; ASSOCIATION
英文摘要:

Objectives: To investigate the relationship between serum level of homocysteine (Hcy) and carotid artery atheroscleosis (CAA).

Methods: Both sides of the common carotid artery and internal carotid artery in 126 Chinese patients with ischemic stroke were measured by B-mode ultrasound. The patients were divided into groups: normal, A, B, C and D according to the severity of CAAs. With fasting serum, Hcy as well as folate, vitamin B-12 and lipids were detected. The mean +/- SD age was 64 +/- 13 years ( range 39 - 87 years).

Results: In a logistic regression model, the Hcy concentrations were associated with an elevated risk of CAAs independent of all traditional risk factors, and when CAAs became severer, the serum Hcy was higher. The levels of the normal group and A, B, C, D groups were 13.22 +/- 6.15 mu mol/l, 16.29 +/- 9.81 mu mol/l, 19.49 +/- 11.16 mu mol/l, 27.21 +/- 17.47 mu mol/l, and 24.14 +/- 8.64 mu mol/l, respectively. Rank test showed a significant difference between normal and other groups (p < 0.05). The levels of folate and vitamin B-12 were negatively correlated with the Hcy concentrations. Spearman correlation coefficient were -0.23 and -0.42 (p < 0.05).

Conclusions: Hyperhomocysteinaemia is an independent risk factor of CAAs and the degree of CAAs is highly correlated with the level of Hcy in serum. The causes of hyperhomocysteinemia may be the result from the decrease in folate and vitamin B-12. Clinical trials are now required to evaluate the effect of treatment with these vitamins on the primary and secondary prevention of cerebral vascular diseases.

语种: 英语
WOS记录号: WOS:000235151100005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68294
Appears in Collections:北京大学第三临床医学院_神经内科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Neurol, Beijing 100083, Peoples R China

Recommended Citation:
Wang, HL,Fan, DS,Zhang, H,et al. Serum level of homocysteine is correlated to carotid artery atherosclerosis in Chinese with ischemic stroke[J]. NEUROLOGICAL RESEARCH,2006,28(1):25-30.
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