IR@PKUHSC  > 北京大学第三临床医学院  > 超声诊断科
学科主题医学影像学
应用超声造影评估慢性肝炎患者肝纤维化分期的研究
其他题名Noninvasive evaluation of hepatic fibrosis stages by contrast enhanced ultrasonography parameters
张明博; 曲恩泽; 钱林学; 王金锐
关键词超声检查 微气泡 肝硬化 Ultrasonography Microbubbles Liver Cirrhosis
刊名中华超声影像学杂志
2010
DOI10.3760/cma.j.issn.1004-4477.2010.11.008
19期:11页:943-947
收录类别中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型Journal Article
摘要目的 探索超声造影无创评估肝纤维化分期的可行性,并评价相关指标的诊断价值.方法 对86例慢性肝炎患者行肝超声造影,以肝穿刺活检作为金标准进行对照.取部分肝实质为感兴趣区,通过时间强度曲线计算门静脉-肝动脉曲线下面积比(Qp/Qa)、门静脉-肝动脉灌注强度比(Ip/Ia)、肝实质灌注下降速率(β)和门静脉主干灌注时间(Tp).用单因素方差分析研究不同肝纤维化分期患者上述参数的变化,Spearman秩相关分析上述参数与肝纤维化分期的关系,ROC曲线分析各参数的诊断价值.结果 随着肝纤维化程度增加,Tp、β逐渐增加,Ip/Ia和Qp/Qa逐渐减少,各组间差异有统计学意义(P<0.05),且上述参数与肝纤维化分期显著相关(P<0.05).分期为≥S1,≥S2,≥S3,S4时Ip/Ia的ROC曲线下面积分别为0.931,0.884,0.820,0.846.分期为≥S1,≥S2,≥S3,S4时Qp/Qa的ROC曲线下面积分别为0.914,0.813,0.845,0.869.结论 根据肝实质超声造影时间强度曲线计算的参数Tp、Ip/Ia、Qp/Qa和β与肝纤维化分期相关,其中Ip/Ia和Qp/Qa可作为超声造影无创评估肝纤维化分期的新指标. Objective To discuss the feasibility of non-invasive quantitative evaluation of hepatic fibrosis by contrast-enhanced ultrasonography (CEUS) parameters. Methods CEUS of liver and liver biopsy were performed in 86 patients. CEUS parameters including area under curve of portal vein/hepatic artery(Qp/Qa) ,perfusion intensity of portal vein/hepatic artery(Ip/Ia), decreasing rate of liver parenchyma perfusion (β) and perfusion time of portal vein (Tp) were calculated based on CEUS images. Differences of the four parameters among stages of hepatic fibrosis were analyzed by ANOVA and Spearman rank correlation test was applied to analyze correlation between parameters and hepatic fibrosis stages. Areas under receiver operating characteristic (ROC) curves were calculated to evaluate the diagnostic accuracy of parameters. Results Tp and β had increasing tend while Ip/Ia and Qp/Qa had declining tend from S0 to S4.They were significantly correlated with fibrosis stage( P <0.05=. The areas under ROC curves of Ip/Ia were 0.931 (≥S1) ,0.884(≥S2 ) ,0.820(≥S3 ) and 0.846(S4 ) respectively. The areas under ROC curves of Qp/Qa were 0.914(≥S1),0.813(≥S2),0.845(≥S3) and0.869 (S4) respectively. Conclusions CEUS parameters of liver parenchyma Ip/la, Qp/Qa, Tp and β are related to fibrosis stages. Ip/Ia and Qp/Qa provide a reliable,non-invasive method for evaluating fibrosis stages.
语种中文
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文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68442
Collection北京大学第三临床医学院_超声诊断科
作者单位1.北京大学第三医院超声科,100191
2.北京友谊医院超声科
Recommended Citation
GB/T 7714
张明博,曲恩泽,钱林学,等. 应用超声造影评估慢性肝炎患者肝纤维化分期的研究[J]. 中华超声影像学杂志,2010,19(11):943-947.
APA 张明博,曲恩泽,钱林学,&王金锐.(2010).应用超声造影评估慢性肝炎患者肝纤维化分期的研究.中华超声影像学杂志,19(11),943-947.
MLA 张明博,et al."应用超声造影评估慢性肝炎患者肝纤维化分期的研究".中华超声影像学杂志 19.11(2010):943-947.
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