IR@PKUHSC  > 北京大学第三临床医学院  > 成形外科
学科主题整形医学
巢蛋白在人胚胎胰腺中的表达
其他题名The expression of nestin in human fetal pancreas
夏修金; 鲍卫汉; 陈东明; 洪天配; 张玲; 郑宗梅; 郭文媛
关键词胰腺 胚胎 干细胞 Stem Cell
刊名中国糖尿病杂志
2003
DOI10.3321/j.issn:1006-6187.2003.03.016
11期:3页:204-207
收录类别中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型Journal Article
摘要目的探讨人胚胎胰腺中干细胞特异性标志巢蛋白(Nestin) 的表达及阳性细胞的分布. 方法用连续切片免疫组织化学染色方法检测16周胎龄人胚胎胰腺中巢蛋白、胰岛素、胰升糖素和导管上皮标志细胞角蛋白19(CK19)的表达及分布. 结果 16周人胚胎胰腺中可检测到巢蛋白阳性细胞,分布于胰岛以及胰导管和腺泡结构中,并且以腺泡结构和小导管中的数目为多.部分胰岛素和CK19染色强阳性的细胞中巢蛋白染色为弱阳性,胰升糖素强阳性的部位则未见巢蛋白染色阳性的细胞. 结论人胚胎胰腺中存在巢蛋白表达的细胞;巢蛋白阳性细胞可能是胰腺组织中一个特殊的细胞亚群,代表了一群未成熟细胞. Objective To investigate whether nestin-expressing cells are present in human fetal pancreas and the cells distribution. Methods Immuno- histochemical staining was used to determine the expression and distribution of nestin, insulin, glucagon and cytokeratin 19 (CK19) in the consecutive sections prepared from human fetal pancreas at 16 weeks of gestation. Results There were nestin-expressing cells in the 16-week human fetal pancreas. These cells resided in the islets of Langerhans, pancreatic ductal and acinic structures, and were the most abundant in both acini and small ducts. Some of the insulin and CK19 positively staining cells were positive for nestin expression. There were no nestin positive cells within the areas where glucagon-expressing cells resided. Conclusion The cells expressing nestin, a marker for pancreatic stem cells, may be a subpopulation of immature cells in the human fetal pancreas.
语种中文
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文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68585
Collection北京大学第三临床医学院_成形外科
作者单位1.100083,北京大学第三医院成形外科研究中心
2.100083,北京大学第三医院内分泌科
3.100083,北京大学干细胞研究中心
Recommended Citation
GB/T 7714
夏修金,鲍卫汉,陈东明,等. 巢蛋白在人胚胎胰腺中的表达[J]. 中国糖尿病杂志,2003,11(3):204-207.
APA 夏修金.,鲍卫汉.,陈东明.,洪天配.,张玲.,...&郭文媛.(2003).巢蛋白在人胚胎胰腺中的表达.中国糖尿病杂志,11(3),204-207.
MLA 夏修金,et al."巢蛋白在人胚胎胰腺中的表达".中国糖尿病杂志 11.3(2003):204-207.
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