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神经功能指数评价不同腓神经修复方式对神经功能恢复的影响
其他题名Evaluating the effects of different peroneal neurorrhaphies on functional recovery by nerve function index
秦荣生; 李健宁; 赵一鸣; 秦泽莲; 马勇光; 王侠; 牛星焘; 李东
关键词腓神经 分析 功能性
刊名中国临床康复
2004
DOI10.3321/j.issn:1673-8225.2004.16.051
8期:16页:3202-3203
文章类型Journal Article
摘要背景:目前已有大量文献证实了神经功能指数评价鼠坐骨神经损伤后功能恢复程度的可靠性,且经常被用来评价大鼠坐骨神经及其分支损伤后功能恢复的程度.目的:本文拟用神经功能指数评价不同腓神经修复方式对神经功能的影响.设计:随机对照的研究.地点和材料:实验在北京大学医学部动物实验室完成,所需的实验材料为20只SD鼠.方法:将大鼠随机分为两组,两组中作为支持神经的胫神经均先行去外膜的"开窗"术,第1组行腓神经与胫神经"开窗"端侧缝合,第2组行腓神经与胫神经"开窗"的侧侧缝合.分别在术后的3,6,11,16周通过足印分析法计算出这两组的腓神经功能指数(peroneal nervefunctional index,PFI),用t检验比较两组功能指数的差异.主要观察指标:术后不同时间点两实验组PFI的差异.结果:术后6周:第1组PFI为-39.92±11.67,第2组PFI为-64.49±31.31,差异有显著性意义(t=-2.315,P=0.033);术后16周:第1组PFI为-27.43±12.54,第2组PFI为-15.66±9.81,差异有显著性意义(t=2.314,P=0.048).结论:腓神经术后16周鼠类腓神经与胫神经侧侧缝合修复法功能恢复较端侧缝合法优. BACKGROUND: The reliability of nerve function index(NFI) for evaluating functional recovery following rat sciatic nerve injury has been confirmed by many researches; moreover, NFI has been commonly used to assess functional recovery after sciatic nerve injury and its branches injuries in rat model.OBJECTIVE: To assess the effect of different peroneal neurorrhaphy on nerve function recovery by NFI.DESIGN: A randomised case-control study.SETTINGS and MATERIALS: The experiment was conducted at the Experimental Animal laboratory of Peking University Health Siences Center. Totally twenty SD rats were used.METHODS: All rats were randomly divided into two groups after removing a small epineural window at tibial nerve (TN) that used as donor nerve. The distal end of PN was sutured to the lateral face of the TN in group A, while PN and TN were reinnervated by side -to-side neurorraphy in group B. Footprint analysis was used to calculate Peroneal nerve function index(NFI) of the two groups at 3, 6, 11, 16 weeks after operation,and the difference of PFI between two groups was compared with t test.MAIN OUTCOME MEASURES: The difference of PFI between two groups at different postoperative time points.RESULTS: PFI was - 39. 92 + 11.67 in group A at 6th week postoperatively, significantly different from -64.49 +31.31 of group B, (t = -2. 315,P = 0. 033) PFI was - 27.43 ± 12.54 in group A and - 15.66 ± 9.81 in group B at 16 weeks postoperatively, with significant difference( t = 2. 314,P=0. 048).CONCLUSION: Side-to-side reinnervation by PN and TN was superior to distallateral neurorraphy for nerve functional recovery at 16 weeks after PN operation in rat models.
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文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68751
专题北京大学第三临床医学院_成形外科
作者单位北京医科大学第三临床医学院成形外科,北京市,100083
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秦荣生,李健宁,赵一鸣,等. 神经功能指数评价不同腓神经修复方式对神经功能恢复的影响[J]. 中国临床康复,2004,8(16):3202-3203.
APA 秦荣生.,李健宁.,赵一鸣.,秦泽莲.,马勇光.,...&李东.(2004).神经功能指数评价不同腓神经修复方式对神经功能恢复的影响.中国临床康复,8(16),3202-3203.
MLA 秦荣生,et al."神经功能指数评价不同腓神经修复方式对神经功能恢复的影响".中国临床康复 8.16(2004):3202-3203.
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