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心得安运动激发试验对儿童生长激素缺乏症的诊断价值
其他题名Diagnostic value of the propranolol-exercise provocative test for growth hormone deifciency in children
郑方圆; 王雪梅; 王新利
关键词心得安运动激发试验 胰岛素激发试验 生长激素缺乏症 儿童 Propranolol-exercise Provocative Test Insulin Provocative Test Growth Hormone Deifciency Child
刊名中国当代儿科杂志
2015
DOI10.7499/j.issn.1008-8830.2015.02.015
2页:180-184
收录类别中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型Journal Article
摘要目的:探讨心得安运动激发试验对儿童生长激素缺乏症(GHD)的诊断价值。方法选择在2009年1月至2013年3月期间因身材矮小症住院,同时完善胰岛素激发和心得安运动激发两项试验的儿童,共120例,记录激发试验前后静脉血GH值。将激发试验后血GH峰值<10 ng/mL定义为激发阴性,GH峰值≥10 ng/mL定义为激发阳性。将两项激发试验后血GH峰值均<10 ng/mL者诊断为GHD。结果120例矮小儿童中,诊断为GHD者29例(24.2%)。胰岛素激发试验阳性率为48.3%。心得安运动激发试验阳性率为65.8%。两项激发试验的总符合率为62.5%,阳性符合率为79.3%。心得安运动激发后血GH峰值显著高于胰岛素激发试验的GH峰值。胰岛素激发试验血GH峰值多出现在试验后30~60 min,心得安运动激发试验GH峰值多出现在试验后的120 min。心得安运动激发试验未见不良反应发生。结论心得安运动激发试验与胰岛素激发试验对GH的激发结果符合率较高,且比胰岛素激发试验更易刺激GH分泌,临床可考虑同时应用胰岛素激发试验、心得安运动激发试验联合诊断GHD。 Objective To assess the diagnostic value of the propranolol-exercise provocative test for growth hormone deficiency (GHD) in children. Methods This study included 120 children who received both the insulin provocative test and the propranolol-exercise provocative test due to short stature between January 2009 and March 2013. Growth hormone (GH) levels in venous blood were measured before and after the provocative test. Peak GH<10 ng/mL was deifned as negative stimulation, while peak GH≥10 ng/mL was deifned as positive stimulation. The children whose peak GH levels were<10 ng/mL after both tests were diagnosed with GHD. Results Twenty-nine (24.2%) of the 120 children with short stature were diagnosed with GHD. The positive rate in the insulin provocative test was 48.3%, versus 65.8%in the propranolol-exercise provocative test. The overall coincidence rate and positive coincidence rate of the two tests were 62.5% and 79.3%, respectively. The peak GH after the propranolol-exercise provocative test was signiifcantly higher than that after the insulin provocative test (P<0.01). Peak GH occurred mostly at 30-60 minutes after the insulin provocative test, while that occurred mostly at 120 minutes after the propranolol-exercise provocative test. No adverse effects were observed in the propranolol-exercise provocative test. Conclusions Coincidence rates in stimulating the secretion of GH are high between the propranolol-exercise provocative test and the insulin provocative test. Compared with the insulin provocative test, the propranolol-exercise provocative test is more likely to stimulate the secretion of GH. GHD can be clinically diagnosed by the insulin provocative test combined with the propranolol-exercise provocative test.
语种中文
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文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/69035
专题北京大学第三临床医学院_儿科
作者单位北京大学第三医院儿科 北京 100191
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郑方圆,王雪梅,王新利. 心得安运动激发试验对儿童生长激素缺乏症的诊断价值[J]. 中国当代儿科杂志,2015(2):180-184.
APA 郑方圆,王雪梅,&王新利.(2015).心得安运动激发试验对儿童生长激素缺乏症的诊断价值.中国当代儿科杂志(2),180-184.
MLA 郑方圆,et al."心得安运动激发试验对儿童生长激素缺乏症的诊断价值".中国当代儿科杂志 .2(2015):180-184.
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