北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 儿科  > 期刊论文
学科主题: 儿科学
题名:
新生儿双胎输血综合征的临床研究
其他题名: Clinical study of neonatal twin-twin transfusion syndrome
作者: 潘维伟; 童笑梅
关键词: 双胎输血综合征 ; 激光治疗 ; 预后 ; 新生儿 ; Twin-twin transfusion syndrome ; Laser surgery ; Prognosis ; Neonate
刊名: 中国当代儿科杂志
发表日期: 2015
DOI: 10.7499/j.issn.1008-8830.2015.05.003
期: 5, 页:430-434
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的:探讨不同分级、不同宫内干预和不同血流供输结果双胎输血综合征(twin-twin?transfusion?syndrome,?TTTS)患儿的临床表现及近期预后。方法对76例新生儿病房住院的TTTS患儿的住院病案资料进行回顾性研究。将入选对象按以下3种方法分组:(1)按照TTTS分级分为轻度TTTS组(n=38)和重度TTTS组(n=21);(2)按照不同宫内干预方法分为羊水减量组(n=20)、激光治疗组(n=21)和期待治疗组(n=32);(3)按照输血对象分为供血儿组(n=23)和受血儿组(n=30)。结果重度TTTS组脑损伤、心脏病变、生后窒息、肾功能损害的发生率和住院期间病死率均高于轻度TTTS组,但差异无统计学意义。激光治疗组脑损伤、心脏病变、肾功能损害的发生率和住院期间病死率有低于羊水减量组和期待治疗组的趋势。受血儿组心脏病变和病理性黄疸的发生率高于供血儿组,差异有统计学意义(P<0.05)。供血儿组生后窒息和肾功能损害的发生率高于受血儿组,但差异无统计学意义。结论 TTTS分级高者器官损伤发生率和住院期间病死率相对高。激光治疗较期待治疗和羊水减量治疗的TTTS患儿的预后可能更佳。受血儿更易发生心脏病变、病理性黄疸,供血儿发生生后窒息和肾脏损害的倾向高于受血儿。 ObjectiveTo explore the clinical manifestations and short-term prognosis of twin-twin transfusion syndrome (TTTS) in neonates with different disease stages, receiving different intrauterine interventions, or as blood donors and recipients.MethodsThe study retrospectively collected 76 TTTS neonates who were hospitalized in the Neonatal Ward, Peking University Third Hospital. The participants were classiifed into mild TTTS (n=38) and severe TTTS groups (n=21), or into amnioreduction (n=20), laser surgery (n=21), and expectant therapy groups (n=32), or into donor (n=23) and recipient groups (n=30).ResultsThe severe TTTS group had higher incidences of brain injury, heart disease, asphyxia, and renal damage and in-hospital mortality rate compared with the mild TTTS group, but the differences had no statistical signiifcance. The laser surgery group displayed decreasing trends in the incidences of brain injury, heart disease, and renal damage and in-hospital mortality rate compared with the amnioreduction and expectant therapy groups. The recipient group had higher incidences of heart diseases and pathological jaundice than the donor group (P<0.05). The donor group had higher incidences of asphyxia and renal damage than the recipient group, but with no signiifcant difference.ConclusionsThe neonates with severe TTTS have higher rates of organ damages and in-hospital mortality. Intrauterine laser surgery seems to lead to a better prognosis compared with the amnioreduction and expectant therapy. The recipients are more susceptible to heart diseases and pathological jaundice, whereas the donors are more susceptible to asphyxia and renal damage.
语种: 中文
原文出处: 查看原文
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/69038
Appears in Collections:北京大学第三临床医学院_儿科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 北京大学第三医院儿科 北京 100191

Recommended Citation:
潘维伟,童笑梅. 新生儿双胎输血综合征的临床研究[J]. 中国当代儿科杂志,2015(5):430-434.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[潘维伟]'s Articles
[童笑梅]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[潘维伟]‘s Articles
[童笑梅]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace