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学科主题: 耳鼻咽喉科学
题名:
两种方法诊断咽喉反流患者的嗓音特征及治疗前后变化
其他题名: Voice characteristics and changes before and after treatment of laryngopharyngeal reflux patients diagnosed by two diagnostic methods
作者: 闫燕; 万苡辰; 刘庆松; 马芙蓉
关键词: 诊断 ; 治疗 ; 食管pH监测 ; 咽喉反流 ; 反流症状指数量表 ; 反流体征评分量表 ; Diagnosis ; THERAPY ; Esophageal pH Monitoring ; laryngopharyngeal reflux ; reflux symptom index ; reflux finding score
刊名: 中国耳鼻咽喉头颈外科
发表日期: 2015
DOI: 10.16066/j.1672-7002.2015.09.003
期: 9, 页:442-444
收录类别: 中国科技核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的用pH监测和反流症状指数量表(reflux symptom index,RSI)联合反流体征评分量表(reflux finding score,RFS)分别诊断咽喉反流,了解质子泵抑制剂治疗前后两种不同方法诊断咽喉反流患者嗓音学参数的变化,以期将嗓音改变作为咽喉反流疾病诊断和疗效判断的辅助指标之一。方法2012年8月~2013年8月在北京大学第三医院耳鼻咽喉科就诊,应用24小时多通道腔内阻抗及pH监测诊断为咽喉反流的患者26例,作为pH组;通过RSI、RFS诊断为咽喉反流的患者26例为量表组,无任何咽喉部不适的志愿者52名为对照组,对所有研究对象应用M DV P软件进行嗓音学参数检查;对实验组患者进行埃索美拉唑20 mg,2次/d,口服治疗,治疗1个月后复查嗓音学参数,分析治疗前、后患者嗓音学参数的差异。结果咽喉反流患者与正常对照组之间比较,质子泵抑制剂治疗前频率微扰、振幅微扰、噪谐比均有显著性差异(P均<0.05);基频、最长发音时间无显著性差异;治疗后上述各嗓音声学参数与对照组之间比较均无显著性差异(P均>0.05);结论咽喉反流患者存在嗓音声学参数的异常,质子泵抑制剂治疗后明显好转,某些嗓音学参数有可能作为咽喉反流疗效评估的客观指标之一。 [ABSTRACT]OBJECTIVETo diagnose laryngopharyngeal reflux (LPR) by using two methods: 24h pH monitoring and RSI combined with RFS scales. To research the voice characteristics of patients with LPR and changes of voice parameters before and after PPIs therapy, and to use voice parameters to help diagnosing and evaluating treatment effect of LPR.METHODSThe patients visited department of Otolaryngology head & neck surgery of Peking University Third Hospital from August 2012 to August 2013 were included in this study. There were 26 LPR patients diagnosed by 24 hr pH-MII monitoring (pH group) and 26 LPR patients diagnosed by RSI combined with RFS (questionnaire group). Another 52 subjects without laryngeal or pharyngeal symptoms were as control group. All subjects underwent MDVP examination. The patients from pH group and questionnaire group took esomeprazole 20 mg bid for one month, afterwards MDVP was examined again. The voice related parameters were compared before and after medication therapy.RESULTSComparing data between LPR patients and normal subjects, Jitter, Shimmer, NHR had significant difference (P<0.05), and F0, MPT had no significant difference (P>0.05) before treatment. After PPIs therapy there was no significant difference between each group (P>0.05).CONCLUSIONAbnormal voice parameters were existed in LPR patients. After PPIs treatment, voice related parameters improved apparently.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/69254
Appears in Collections:北京大学第三临床医学院_耳鼻喉科_期刊论文

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作者单位: 北京大学第三医院耳鼻咽喉头颈外科 北京 100191

Recommended Citation:
闫燕,万苡辰,刘庆松,等. 两种方法诊断咽喉反流患者的嗓音特征及治疗前后变化[J]. 中国耳鼻咽喉头颈外科,2015(9):442-444.
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