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学科主题: 放射科学
题名:
载平阳霉素离子交换型微球的药代动力学研究
其他题名: Pharmacokinetics of ion-exchange microsphere loaded with pingyangmycin
作者: 高洁; 李选; 萨尔阿; 范田园
关键词: 平阳霉素 ; 微球 ; 药物动力学 ; 栓塞 ; pingyangmycin ; microspheres ; pharmacokinetic ; embolism
刊名: 中国临床药理学杂志
发表日期: 2015
DOI: 10.13699/j.cnki.1001-6821.2015.03.014
期: 3, 页:203-205,211
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的:探讨载平阳霉素离子交换型微球( PYM-MS)在兔体内的药代动力学特征。方法健康成年日本大耳白兔12只,雌雄各半,随机分为2组,每组6只。兔颈外动脉为实验模型,分别注射平阳霉素溶液( PYM)和PYM-MS。于2,5,10,20,40,60,90,120 min依次取血,处理血样,用高效液相色谱法( HPLC)测定平阳霉素浓度,绘制血药浓度-时间曲线,计算药代动力学参数。结果PYM-MS组与PYM组相比,血药浓度-时间曲线下降缓慢;PYM-MS组Cmax (11.62±2.66) mg· L-1较PYM组的(58.96±4.51)mg· L-1小(P<0.01);PYM-MS 组与 PYM 组的 AUC 分别为(221.06±31.33),(791.98±55.30) mg· L-1· min( P<0.01);PYM-MS组体内平均滞留时间( MRT0-60 min )延长,2组分别为(22.29±1.52),(14.20±1.24)min(P<0.01)。结论 PYM-MS有缓释作用,外周血药浓度低。 Objective To investigate the characteristics of pharmacoki-netics of pingyangmycin ion -exchanged microspheres in rabbits.Methods A total of 12 Japanese rabbits, half male and half female, were randomly divided into group A and group B.The rabbits in group A and group B were injected with PYM and PYM-MS via external carotid artery separately.The blood samples were obtained at 2, 5, 10, 20, 40, 60 ,90 and 120 minutes after injection and detected by HPLC method.The parameters of pharmacokinetics were analyzed.Results Compared with group A, it showed a slow decrease in terms of concentration-time curves of pingyangmycin in rabbits after administration of PYM-MS in group B;the Cmax [(11.62 ±2.66) vs (58.96 ±4.51) mg· L-1 ] and AUC [(21.06 ±31.33) vs (791.98 ±55.30) mg· L-1 · min] in group B were significantly lower ( P <0.01 ) , but the data of MRT0-60 min was longer in group B [ ( 22.29 ±1.52 ) vs ( 14.20 ±1.24 ) min ] , P <0.01.Conclusion PYM-MS showed definite property of delayed drug release, with a lower plasma concentration.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/69362
Appears in Collections:北京大学第三临床医学院_放射科_期刊论文

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作者单位: 1.北京大学 第三医院 放射科,北京,100083
2.北京大学 第三医院 介入血管外科,北京,100083
3.北京大学医学部药学院,北京,100191

Recommended Citation:
高洁,李选,萨尔阿,等. 载平阳霉素离子交换型微球的药代动力学研究[J]. 中国临床药理学杂志,2015(3):203-205,211.
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