IR@PKUHSC  > 北京大学第三临床医学院  > 放射科
其他题名Full-Joint Coverage Delayed Gadolinium-Enhanced MRI of Cartilage:Preliminary Study in Vitro
郑卓肇; 李洁; 李选
关键词磁共振成像 钆喷替酸葡甲胺 软骨 Magnetic Resonance Imaging 关节 Gadopentetate Dimeglumine Cartilage Anticular
收录类别中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型Journal Article
摘要目的:探讨多层IR-TSE和可变翻转角三维FLASH序列实现全关节软骨t1值测量的可行性.材料和方法:针对模型(不同浓度的稀释Gd-DTPA溶液)和离体牛软骨,分别利用多层IR-TSE和可变翻转角三维FLASH序列进行t1值测量.以单层IR-TSE测量结果为参照标准,验证上述两种技术的可行性.结果:在模型中,多层IR-TSE与单层IR-TSE测量值的相关系数为1.000(P<0.001);三维FLASH与单层IR-TSE测量值的相关系数为0.997(P<0.001).在离体牛软骨延迟钆增强MR软骨成像中,单层IR-TSE、多层IR-TSE和三维FLASH均显示胰蛋白酶处理侧软骨的t1值显著低于对照侧软骨.多层IR-TSE与单层IR-TSE相比较,对照侧、处理侧和总体软骨t1值的相关系数分别为0.821(P=0.012)、0.968(P=0.001)和0.953(P=0.001);三维FLASH与单层IR-TSE相比较,对照侧、处理侧和总体软骨t1值的相关系数分别为0.199(P=0.637)、0.757(P=0.030)和0.755(P=0.001).结论:多层IR-TSE和可变翻转角三维FLASH序列均可用于全关节软骨的t1值测量. Purpose To investigate the feasibility of T1 measurement using multi-slice inversion recovery turbo spin echo (IR-TSE) and variable flip angle three-dimensional fast low angle shot (3D FLASH) for full-joint coverage delayed gadolinium enhanced MRI of the cartilage. Materials and Methods MR phantoms using dilated gadolinium solution with different concentrations and ex vivo bovine cartilages were scanned using multi-slice IR-TSE and variable flip angle 3D FLASH sequences and the T1 values were calculated. The referring T1 value were obtained using single slice IR-TSE sequence. Results On phantom study, the correlation coefficiencies between multi-slice IR-TSE, 3D FLASH sequences and single slice IR-TSE was 1.000 and 0.997, respectively, where P<0.001 on ex vivo bovine cartilage study, the T1 values of the trypsin degraded species measured by single-slice, multi-slice IR-TSE and 3D-FLASH were significantly lower than the control species. The correlation coefficiency between single-slice and multi-slice IR-FSE on the control group, the trypsin degraded group and both was 0.821(P=0.012), 0.968(P=0.001), and 0.953(P=0.001) respectively. The correlation coefficiency between single-slice IR-FSE and 3D-FLASH on the trypsin degraded group, control group and both was 0.199(P=0.637), 0.757(P=0.030), and 0.775(P=0.001) respectively, where P<0.001. Conclusion Both Multi-slice IR-TSE and variable flip angle 3D-FLASH sequences can be applied for T1 measurement of the full joint cartilage.
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作者单位北京大学第三医院放射科 北京 100191
Recommended Citation
GB/T 7714
郑卓肇,李洁,李选. 延迟Gd-DTPA增强MR软骨成像:全关节软骨成像的可行性分析[J]. 中国医学影像学杂志,2010,18(1):14-18.
APA 郑卓肇,李洁,&李选.(2010).延迟Gd-DTPA增强MR软骨成像:全关节软骨成像的可行性分析.中国医学影像学杂志,18(1),14-18.
MLA 郑卓肇,et al."延迟Gd-DTPA增强MR软骨成像:全关节软骨成像的可行性分析".中国医学影像学杂志 18.1(2010):14-18.
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