北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 风湿免疫科  > 期刊论文
学科主题: 免疫学
题名:
抗核仁蛋白B23抗体在系统性硬化病患者中的临床意义探讨
其他题名: The clinical significance of anti-nuclear protein B23 in systemic sclerosis
作者: 姚中强; 马军; 刘湘源; 王国峰; 于孟学
关键词: 核蛋白类 ; 酶联免疫吸附测定 ; 高血压,肺性 ; Logistic模型 ; Nucleoproteins ; Enzyme-linked immunosorbent assay ; Hypertension,pulmonary ; Logistic models
刊名: 中华风湿病学杂志
发表日期: 2011
DOI: 10.3760/cma.j.issn.1007-7480.2011.03.010
卷: 15, 期:3, 页:179-182
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的 探讨抗核仁蛋白 B23抗体在系统性硬化病(SSc)患者中的临床意义.方法 采用酶联免疫吸附试验(ELISA)法检测SSc患者血清中抗核仁蛋白B23抗体,非参数检验比较抗核仁蛋白B23抗体阳性组和阴性组之间临床表现和免疫指标的差异,使用Logistic回归分析抗核仁蛋白B23抗体与患者临床表现、免疫指标的相关性.结果 纳入156例SSc患者,其中抗核仁蛋白B23抗体36例阳性,占23.1%.非参数检验表明,抗核仁蛋白B23抗体阳性组的用力肺活量(FVC)、肺一氧化碳弥散功能(DLco)明显低于B23抗体阴性组;肺动脉高压发生率更高,抗着丝点抗体、抗U1RNP抗体和抗核仁纤维蛋白抗体阳性率更高.多因素Logistic回归分析表明,抗核仁蛋白B23抗体阳性是SSc患者发生肺动脉高压的独立危险因素(OR=123.92,95%CI 26.67~575.66,P<0.01),是严重胃肠道受累的保护性因素(OR=0.08,95%CI 0.01~0.70,P<0.05).Logistic回归分析表明,抗核仁蛋白B23抗体与抗核仁纤维蛋白抗体(OR=11.50,95%CI 3.85~34.37,P<0.O1)、抗U1RNP抗体相关(OR=3.43,95%CI 1.01~11.63,P<0.05),与不同程度肺动脉高压均显著相关.结论 抗核仁蛋白B23抗体阳性患者应该严密监测其肺动脉压力. Objective To explore the clinical significance of anti-nuclear protein B23 antibody in systemic sclerosis. Methods Enzyme-linked immunosorbent assay was employed to detect the serum antinuclear B23 autoantibody. Mann-Whitney U test was used to compare the clinical and autoantibody profiles between SSc patients with B23 antibody and those without B23 antibody. Logistic regression analysis was employed to analyze the correlation between B23 antibody and clinical manifestations and autoantibody profiles. Results Mann-Whitney U test showed that, forced vital capacity (FVC) diffusion capacity of CO (DLco) in B23 positive SSc was significantly lower than that in B23 negative counterparts, pulmonary artery hypertension was more prevalent in B23 positive SSc patients. While anti-fibrillarin, anti-U1RNP, and antic entromere antibodies were more prevalent in B23 positive SSc. Multivariate logistic regression showed that anti-B23 antibody positivity was an independent risk factor for pulmonary artery hypertension in SSc (OR=123.92, 95%CI 26.67~575.66, P<0.01), and a protective factor for severe gastrointestinal involvement (OR=0.08, 95%CI 0.01 ~0.70, P<O.05). Logistic analysis showed that anti-B23 antibody was correlated with antifibrillarin (OR=11.50, 95%CI3.85~34.37, P<0.01) and anti-U1RNP antibodies (OR=3.43, 95%CI 1.01~11.63, P<0.05), and correlated with different degree of pulmonary artery hypertension. Conclusion The pulmonary artery pressure should be monitored closely in those SSc patients with a positive B23 antibody.
语种: 中文
原文出处: 查看原文
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/69680
Appears in Collections:北京大学第三临床医学院_风湿免疫科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.北京大学第三医院风湿免疫科,100191
2.长治医学院附属和平医院医学部
3.河北省廊坊市管道局医院风湿免疫科
4.中国医学科学院,北京协和医院风湿免疫科

Recommended Citation:
姚中强,马军,刘湘源,等. 抗核仁蛋白B23抗体在系统性硬化病患者中的临床意义探讨[J]. 中华风湿病学杂志,2011,15(3):179-182.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[姚中强]'s Articles
[马军]'s Articles
[刘湘源]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[姚中强]‘s Articles
[马军]‘s Articles
[刘湘源]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace