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弥漫结缔组织病患者心血管并发症的临床特点分析
其他题名Analysis for clinical features of cardiovascular complication of diffuse connective tissue disease
邓晓莉; 刘湘源; 赵金霞
关键词弥漫结缔组织病 心血管疾病 预后 Diffuse connective tissue disease Cardiovascular disease Prognosis
刊名北京大学学报(医学版)
2010
DOI10.3969/j.issn.1671-167X.2010.02.006
42期:2页:143-146
文章类型Journal Article
摘要目的:分析弥漫结缔组织病(diffuse connective tissue disease,dCTD)患者的心血管并发症的临床特点和预后,以提高临床医生的认识.方法:回顾性总结和分析1994年到2007年间所有在北京大学第三医院住院、并发心血管病的181例dCTD患者的心血管病临床资料,并进行随访,同时,对比分析dCTD患者各亚组的临床资料和随访情况.结果:因并发心血管病住院列前两位的dCTD为类风湿关节炎(rheumatoid arthritis,RA)和系统性红斑狼疮(systemic lupus erythematosus,SLE),共占67.9%(123/181),dCTD患者最常见的心血管并发症为高血压病、高脂血症和冠心病.并发心血管病的dCTD患者最常见的超声心动图异常依次为瓣膜返流、左心室舒张功能减退、左心房增大、肺动脉高压和心包积液(分别为57.8%、50.6%、33.7%、21.7%和19.3%).与RA亚组相比,SLE亚组的高血压病、冠心病和高脂血症的平均发病年龄均显著偏小(P<0.001,P=0.011,P=0.012),心包积液和左心室增大的发生率显著增高(P<0.001,P=0.03),而左心室舒张功能减退发生率显著降低(P<0.001).合并心血管病的dCTD患者的中位生存时间为9.8年.结论:RA和SLE是因并发心血管病住院最常见的弥漫结缔组织病,dCTD患者最常见的心血管并发症为高血压病、高脂血症和冠心病.弥漫结缔组织病合并心血管病患者预后差.SLE发生心血管病较年轻. Objective:To analyze the clinical features and prognosis of cardiovascular complications of diffuse connective tissue disease(dCTD).Methods:Clinical data of cardiovascular complications of 181 cases of dCTD were retrospectively analyzed.Clinical data of two subsets [rheumatoid arthritis(RA,81)and systemic lupus erythematosus(SLE,42)] were also analyzed.Follow-up was carried out for all the patients.Results:RA and SLE were the most common disease complicated by cardiovascular disease needing hospitalization.The most frequent cardiovascular complications in dCTD patients were hyperten-sion,hyperlipidemia and coronary artery disease.The most common echocardiographic abnormalities were valvular regurgitation,left ventricular diastolic dysfunction,enlargement of left atrium,pulmonary hypertension and pericardial effusion(57.8%,50.6%,33.7%,21.7% and 19.3%,respectively).Compared with the subset of RA,patients were younger at onset of hypertension,coronary artery disease and hyperlipidemia in the subset of SLE [(40±11) vs (56±15),P<0.001;(53±12) vs (64±10),P=0.011;(44±16) vs (58±12),P=0.012,respectively].Both pericardial effusion(P<0.001)and enlargement of left ventricle(P=0.03)were more frequent,and left ventricular diastolic dysfunc-tion was less common(P<0.001).Median survival time of these dCTD patients was 9.8 years.Con-clusion:RA and SLE are the most common diffuse connective tissue diseases complica ted by cardiovas-cular disease needing hospitalization.The most frequent cardiovascular complications in dCTD patients are hypertension,hyperlipidemia and coronary artery disease.The prognosis of dCTD patients complica-ted with cardiovascular diseases is poor.SLE patients are younger at onset of cardiovascular diseases.
语种中文
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文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/69691
专题北京大学第三临床医学院_风湿免疫科
作者单位北京大学第三医院风湿免疫科,北京,100191
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邓晓莉,刘湘源,赵金霞. 弥漫结缔组织病患者心血管并发症的临床特点分析[J]. 北京大学学报(医学版),2010,42(2):143-146.
APA 邓晓莉,刘湘源,&赵金霞.(2010).弥漫结缔组织病患者心血管并发症的临床特点分析.北京大学学报(医学版),42(2),143-146.
MLA 邓晓莉,et al."弥漫结缔组织病患者心血管并发症的临床特点分析".北京大学学报(医学版) 42.2(2010):143-146.
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