北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 妇产科  > 期刊论文
学科主题: 妇产科学
题名:
生长激素在多囊卵巢综合征促排卵中的作用
其他题名: Effect of growth hormone on the outcome of ovulation induction in patients with polycystic ovary syndrome
作者: 王颖; 李美芝; 杨池荪; 王振红; 姜颜彬
关键词: 多囊卵巢综合征 ; 促生长素 ; 排卵诱导
刊名: 中华妇产科杂志
发表日期: 2001
DOI: 10.3760/j.issn:0529-567X.2001.01.011
卷: 36, 期:1, 页:36-39
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的 探讨生长激素(GH)在多囊卵巢综合征(PCOS)患者促排卵中的作用。方法 测定130例PCOS患者(PCOS组)及107例正常妇女(对照组)的血中生殖激素及GH和胰岛素样生长因子Ⅱ(IGF-Ⅱ) 的基础水平,并应用GH辅助促排卵方案治疗7例对人绝经期促性腺激素(hMG)反应不良的PCOS患者,观察疗效。结果 PCOS患者血中GH水平明显降低,肥胖者更为明显,非肥胖与肥胖者分别为(2.50±1.33)μg/L及(1.04±0.47) μg/L, 而对照组肥胖与非肥胖者分别为(2.95±1.49) μg/L、(5.30±2.26) μg/L(P均<0.05); PCOS组肥胖者IGF-Ⅱ水平为(136±27) nmol/L,高于非肥胖者的(123±20) nmol/L,两者比较,差异有显著性(P<0.05)。应用GH辅助促排卵治疗,可以明显减少hMG用量1~12支,缩短hMG刺激时间3~12 d,增加优势卵泡的数量。结论 PCOS患者存在GH分泌障碍,应用GH辅助促排卵可以提高排卵率。 Objective To study the effect of growth hormone (GH) on the outcome of ovulation induction in patients with polycystic ovary syndrome (PCOS). Methods We examined serum sex hormone, GH and insulin like growth factor-Ⅱ(IGF-Ⅱ) basal levels by radioimmunoassay in 130 PCOS patients and 107 normal women. In addition, we observed the effect of GH on the outcome of ovulation induction in 7 poor responders to human menopausal gonadotropin (hMG) treatment. Results The mean serum GH level is (2.50±1.33) μg/L and (1.04±0.47) μg/L respectively in nonobese and obese PCOS patients which were significantly lower than those in controls [(5.30±2.26) μg/L, (2.95±1.49) μg/L respectively, P<0.05]. The mean serum IGF-Ⅱ level is (136±27) nmol/L in the obese PCOS patients, significantly greater than those in nonobese PCOS and controls (P<0.05). When we used GH with hMG in 7 poor responders, the total amount of hMG required decreased from 1 to 12 amples and the duration of treatment shortened as compared with hMG alone. Conclusion There is abnormal GH secretion in patients with PCOS, GH may improve the outcome of ovulation induction by gonadotropin.
语种: 中文
原文出处: 查看原文
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/69876
Appears in Collections:北京大学第三临床医学院_妇产科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 北京大学第三医院妇产科

Recommended Citation:
王颖,李美芝,杨池荪,等. 生长激素在多囊卵巢综合征促排卵中的作用[J]. 中华妇产科杂志,2001,36(1):36-39.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[王颖]'s Articles
[李美芝]'s Articles
[杨池荪]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[王颖]‘s Articles
[李美芝]‘s Articles
[杨池荪]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace