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学科主题: 妇产科学
题名:
过氧化物酶体增殖物激活受体-γ与肿瘤坏死因子-α在重度子(癎)前期发病中相互作用的探讨
其他题名: Interaction between peroxisome proliferator-activated receptor-gamma and tumor necrosis factor-alpha in pathogenesis of severe preeclampsia
作者: 王伽略; 杨孜; 王荣; 朱锦明
关键词: 先兆子(癎) ; PPARγ ; 肿瘤坏死因子α ; 免疫组织化学 ; Preeclampsia ; PPAR gamma ; Tumor necrosis factor-alpha ; Immunohistochamistry
刊名: 中华围产医学杂志
发表日期: 2009
DOI: 10.3760/cma.j.issn.1007-9408.2009.01.005
卷: 12, 期:1, 页:15-19
收录类别: 中国科技核心期刊 ; 中文核心期刊
文章类型: Journal Article
摘要: 目的 探讨过氧化物酶体增殖物激活受体-γ(peroxisome proliferator-activated receptorgamma,PPAR-γ)与肿瘤坏死因子-α(tumor necrosis factor-alpha,TNF-α)在重度子(癎)前期发病中的作用及相互关系.方法 采用免疫组织化学SP法,检测68例不同发病时间的重度子(癎)前期伴或不伴肝损害者胎盘组织PPAR-γ与TNF-α的表达,并与54例早、中、晚孕期正常妊娠绒毛或胎盘组织比较.结果 两组孕妇胎盘组织均有PPAR-γ与TNF-α的表达.正常妊娠中期和妊娠28~32周胎盘PPAR-γ表达明显低于妊娠早期(12.03±6.38,11.17±3.57和18.46±5.27,P<0.05);TNF-α在正常妊娠早期胎盘表达强度高于中期和晚期各组(P<0.05).PPAR-γ/TNF-α比值在正常妊娠各不同孕期组间差异无统计学意义.不同发病孕周的重度子(癎)前期组与正常妊娠组比较,TNF-α表达明显升高(P均<0.05);发病孕周<32周的重度子(癎)前期组与正常妊娠组比较,PPAR-γ/TNF-α比值差异无统计学意义(P<0.05),发病孕周为32一周和>34周两组中,伴或不伴肝损害者PPAR-γ/TNF-α比值均明显低于正常妊娠者(P<0.05).正常妊娠和重度子(癎)前期组内PPAR-7与TNF-a之间未见直线相关性(正常妊娠组r=0.227,P=0.125;重度子(癎)前期组r=0.142,P=0.267).结论 晚发型重度子(癎)前期孕妇胎盘PPAR-γ/TNF-α比值下降可能与较晚发生的子(癎)前期病理变化有关,其在重度子(癎)前期发生发展中复杂的相互作用及调节机制还有待深入研究. Objective To investigate the expression of peroxisome proliferators-activated receptorgamma,PPARγ)and tumor necrosis factor-α(TNF-α)in human placental tissues and to discuss the role of PPARγ and TNF-α in the pathogenesis of severe preeclampsia(SPE). Methods Placenta tissues were obtained from 70 cases of SPE with the onset at different gestations with or without liver impairement.Another 54 placental or villi samples from normal pregnancy at the first,second and third trimester were collected as controls.The protein expression of PPAR7 and TNF-αwere determined by immunohistochemistry.Results Both PPARγ and TNF-α were detected in placentas in all subjects.Among the controls,the expressions of PPARγ in the second trimester and 28-32 weeks of gestation were much lower than that in the first trimester(12.03±6.38 and 11.17±3.57 vs 18.46±5.27,P<0.05),while the TNF-α expressions in the second and third trimester were much lower than that in the first(P<0.05).No significant difference in PPARγ/TNF-α ratios was detected among the three trimesters in normal pregnancy.There was no difference on the expression of PPARγ between SPE and controls,moreover,the expression of TNF-α was dramatically increased in SPE than in controls(P<0.05).PPARγ/TNF-α ratio in SPE women with the onset<32 weeks was much lower than in the controls(P<0.05).Neither group showed linear correlation between the expression of PPARγ and TNF-α.Conclusions The decrease of PPAR-γ/TNF-α ratio may be related to the pathological changes of late-onset precclampsia and secondary to maternal systemic damage.The none linear correlation between PPARγ and TNF-α expression and their interactions in the pathogenesis of SPE warrants further researches.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/69925
Appears in Collections:北京大学第三临床医学院_妇产科_期刊论文

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作者单位: 北京大学第三医院妇产科,100083

Recommended Citation:
王伽略,杨孜,王荣,等. 过氧化物酶体增殖物激活受体-γ与肿瘤坏死因子-α在重度子(癎)前期发病中相互作用的探讨[J]. 中华围产医学杂志,2009,12(1):15-19.
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