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IR@PKUHSC  > 北京大学第三临床医学院  > 妇产科  > 期刊论文
学科主题: 妇产科学
题名:
子痫前期患者胎盘组织中松弛素受体的表达
其他题名: Expression of relaxin receptor in placental tissues of normal pregnancy and pre-eclampsia
作者: 王永清; 李俊; 杨孜
关键词: 先兆子痫 ; 胎盘 ; 受体,G-蛋白偶联 ; 受体,肽 ; Pre-eclampsia ; Placenta ; Receptors,G-protein-coupled ; Receptors,peptide
刊名: 中华妇产科杂志
发表日期: 2008
DOI: 10.3321/j.issn:0529-567X.2008.04.009
卷: 43, 期:4, 页:269-271
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的 探讨子痫前期患者胎盘组织中松弛素受体LGR7表达与子痫前期发病的关系.方法 应用链霉菌抗生物素蛋白-过氧化物酶连接法和RT-PCR技术检测20例正常孕妇(正常组)及26例重度子痫前期孕妇(子痫前期组)胎盘组织中松弛素受体LGR7蛋白及mRNA的表达.结果 (1)两组孕妇的胎盘组织中均有松弛素受体LGR7表达,主要定位于胎盘绒毛滋养细胞的细胞膜上,在细胞滋养细胞、合体滋养细胞中都有较高的表达水平.(2)正常组胎盘组织中松弛素受体LGR7蛋白的表达水平为0.912±0.003,子痫前期组为0.625±0.037,两组比较,差异有统计学意义(P<0.01).(3)正常组胎盘组织中松弛素受体LGR7 mRNA表达水平为0.776±0.021,子痫前期组为0.393±0.075,两组比较,差异有统计学意义(P<0.01).结论 子痫前期患者胎盘组织中松弛素受体表达水平下降,可能与子痫前期的发病有关. Objective To study the location and level of relaxin receptor in placenta tissues of preeclampsia and normal pregnancy,and the relationship of relaxin receptor with pre-eclampsia.Methods Twenty-six placenta tissue samples from pregnant women with severe preeclampsia(study group),and 20samples from normal pregnancies(control group)were obtained.We detected the expression of relaxin receptor by immunohistochemistry and the expression of relaxin receptor mRNA by RT-PCR.Results In the placenta of control and preeclampsia groups,the leucine-rich repeat-containing G protein-coupled receptor(LGR7)was positively expressed.Relaxin receptor was located in the membrane of trophoblast cells.There were both strong signals on cytotrophoblastic cells and syneytiotrophoblast.The level of relaxin receptor in the control group was 0.912 ±0.003.and 0.625±0.037 in the preeclampsia group.Thedifference between the two groups was obvious(P<0.01).In the control group,the level of relaxin receptor mRNA was 0.776±0.021;in the preeclampsia group,it was 0.393±0.075.The difference was obvious(P<0.01).Conclusion Decrease in the expression of relaxin receptor at placenta is related with the occurrence and development of preeclampsia.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/69962
Appears in Collections:北京大学第三临床医学院_妇产科_期刊论文

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作者单位: 1.北京大学第三医院妇产科,100083
2.中国医科大学附属盛京医院妇产科

Recommended Citation:
王永清,李俊,杨孜. 子痫前期患者胎盘组织中松弛素受体的表达[J]. 中华妇产科杂志,2008,43(4):269-271.
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