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学科主题: 妇产科学
题名:
细胞毒性T淋巴细胞相关抗原4编码区49位点的基因多态性与宫颈癌遗传易感性的关系
其他题名: Association between CTLA-4 gene polymorphism and susceptibility to cervical cancer
作者: 李华; 周翊峰; 郭红燕; 孙瞳; 章文华; 林东昕
关键词: 官颈肿瘤 ; 细胞毒性T淋巴细胞相关抗原4 ; 基因多态 ; Cervical neoplasms ; Cytotoxic T lymphocyte-associated antigen 4 ; Genetic polymorphism
刊名: 中华肿瘤杂志
发表日期: 2011
DOI: 10.3760/cma.j.issn.0253-3766.2011.09.009
卷: 33, 期:9, 页:681-684
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的 探讨细胞毒性T淋巴细胞相关抗原4(CTLA-4)编码区49位点的基因多态性与宫颈癌遗传易感性的关系。方法 收集314例宫颈癌患者和320例正常对照者的外周静脉血标本,应用聚合酶链反应-限制性片段长度多态性法,检测CTLA-4 +49 A/G多态位点的基因型。采用多因素Logistic回归法,分析基因多态性与官颈癌发病风险的相关性以及与宫颈癌临床病理特征的关系。结果病例组中CTLA-4 +49 A等位基因和AA基因型的频率分别为32.5%和9.6%,对照组中分别为25.8%和5.6%。携带CTLA-4 +49 AA基因型者患宫颈癌的风险是GG基因型的2.06倍(95% CI 为1.10~ 3.85,P=0.024)。CTLA-4 +49基因多态与官颈癌临床分期、病理类型、分化程度、肿瘤大小和血清鳞状上皮细胞癌抗原水平等临床病理因素均无关(均P >0.05)。结论CTLA-4基因有可能是宫颈癌的遗传易感基因。 Objective To investigate the association between CTLA-4 +49A/G polymorphisms and the risk of susceptibility to cervical cancer. Methods A hospital-based case-control study was conducted.314 cases with primary cervical cancer and 320 healthy controls were collected and genotyped by PCR-based RFLP for +49A/G polymorphisms in the CTLA-4 gene. Results The A allele and AA genotype of CTLA4 gene were 32.5% and 9.6% in the patients, and 25.8% and 5.6% in the controls, respectively.Subjects with CTLA-4 + 49AA genotype conferred a higher risk of cervical cancer (OR = 2.06,95% CI:1.10-3.85;P =0. 024). However, the correlation between AA genotype in CTLA-4 polymorphisms and clinicopathological characteristics was not significant. ConclusionThe results of this study suggest that CTLA4 gene is associated with cervical cancer risk and may be a susceptible gene of cervical cancer.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/70002
Appears in Collections:北京大学第三临床医学院_妇产科_期刊论文

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作者单位: 1.北京大学第三医院妇产科,100191
2.苏州大学医学部肿瘤细胞与分子免疫实验室
3.中国医学科学院肿瘤医院肿瘤研究所病因及癌变研究室
4.中国医学科学院肿瘤医院妇瘤科

Recommended Citation:
李华,周翊峰,郭红燕,等. 细胞毒性T淋巴细胞相关抗原4编码区49位点的基因多态性与宫颈癌遗传易感性的关系[J]. 中华肿瘤杂志,2011,33(9):681-684.
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