|摘要||目的 评价白细胞介素1B(IL-1B)基因的-511C/T、-31T/C、+3954C/T基因多态性与慢性阻塞性肺疾病发病(COPD)的相关性.方法 全面检索PubMed、Embase、Ovid数据库、万方数据库及中国期刊全文数据库获取IL-1B基因多态性与COPD易感性的病例-对照研究,采用等位基因位点、显性遗传模型、隐性遗传模型、共显性遗传模型分别评价COPD发病的相对危险度,并通过人种分组、对各基因多态性进行亚组分析.运用荟萃分析方法综合评价IL-1B基因的-511C/T、-31T/C、+3954C/T基因多态性与COPD的相关性.结果 共有7篇病例-对照研究文献被纳入,荟萃分析结果显示-511C/T、-31T/C、+3954 C/T基因多态性与COPD均无显著相关性,但以人种分组的亚组分析显示:-511C/T的T等位基因在高加索人中与COPD显著相关(OR=1.76,95％ CI为1.22～2.54,P=0.002),但在亚洲人中无相关性(OR=0.94,95％ CI为0.64～1.38,P=0.736).-31T/C的C等位基因在高加索人中与COPD显著相关(OR=0.62,95％ CI为0.40 ～0.97,P=0.035),但在亚洲人中无相关性(OR=1.06,95％ CI为0.89～ 1.26,P=0.533).结论 IL-1B基因多态性与COPD的易感性有人种差异；在高加索人中,IL-1B-511C/T的T等位基因与COPD发病风险呈正相关,IL-1B-31T/C的C等位基因与COPD发病风险呈负相关.
Objective To explore the association between the-511C/T,-31T/C and +3954C/T polymorphisms of interleukin-1B (IL-1 B) gene and chronic obstructive pulmonary disease (COPD) using the method of meta-analysis.Methods Comprehensive searches were performed of PubMed,Embase,Ovid,Wanfang and Chinese journal full-text database to retrieve the related case-control studies.The pooled odds ratios were performed respectively for allele comparison,additive genetic model,dominant genetic model and recessive genetic model and subgroup analysis was also performed by ethnicity.Results Seven case-control studies were included for meta-analysis.Pooled analysis showed that neither-511C/T,-31T/C nor + 3954 C/T polymorphisms increased the susceptibility to COPD.In the subgroup analysis by ethnicity,significant risks were found in the Caucasian population for-511C/T T allele (OR =1.76,95％CI 1.22-2.54,P =0.002),but not in the Asian population(OR =0.94,95％ CI 0.64-1.38,P =0.736).Significant risks were also found in the Caucasian population for-31T/C C allele (OR =0.62,95％ CI 0.40-0.97,P =0.035),but not in the Asian population (OR =1.06,95％ CI 0.89-1.26,P =0.533).Conclusions IL-1B polymorphisms may play a role in the susceptibility of COPD in an ethnicityspecific manner.In the Caucasian population,the risk of COPD was associated positively with the IL-1B -511C/T T allele and negatively with the IL-1B-31T/C C allele.|
梅静静,梁瀛,沈宁,等. 白细胞介素1B基因多态性与慢性阻塞性肺疾病关系的荟萃分析[J]. 中华医学杂志,2013,93(12):910-915.