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学科主题: 呼吸内科学
题名:
白细胞介素1B基因多态性与慢性阻塞性肺疾病关系的荟萃分析
其他题名: Association between interleukin-1B polymorphisms and chronic obstructive pulmonary disease: a meta-analysis
作者: 梅静静; 梁瀛; 沈宁; 贺蓓
关键词: 白细胞介素1 ; 多态性,单核苷酸 ; 肺疾病,慢性阻塞性 ; Meta分析 ; Interleukin-1 ; Polymorphism,single nucleotide ; Pulmonary disease,chronic obstructive ; Meta-analysis
刊名: 中华医学杂志
发表日期: 2013
DOI: 10.3760/cma.j.issn.0376-2491.2013.12.008
卷: 93, 期:12, 页:910-915
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的 评价白细胞介素1B(IL-1B)基因的-511C/T、-31T/C、+3954C/T基因多态性与慢性阻塞性肺疾病发病(COPD)的相关性.方法 全面检索PubMed、Embase、Ovid数据库、万方数据库及中国期刊全文数据库获取IL-1B基因多态性与COPD易感性的病例-对照研究,采用等位基因位点、显性遗传模型、隐性遗传模型、共显性遗传模型分别评价COPD发病的相对危险度,并通过人种分组、对各基因多态性进行亚组分析.运用荟萃分析方法综合评价IL-1B基因的-511C/T、-31T/C、+3954C/T基因多态性与COPD的相关性.结果 共有7篇病例-对照研究文献被纳入,荟萃分析结果显示-511C/T、-31T/C、+3954 C/T基因多态性与COPD均无显著相关性,但以人种分组的亚组分析显示:-511C/T的T等位基因在高加索人中与COPD显著相关(OR=1.76,95% CI为1.22~2.54,P=0.002),但在亚洲人中无相关性(OR=0.94,95% CI为0.64~1.38,P=0.736).-31T/C的C等位基因在高加索人中与COPD显著相关(OR=0.62,95% CI为0.40 ~0.97,P=0.035),但在亚洲人中无相关性(OR=1.06,95% CI为0.89~ 1.26,P=0.533).结论 IL-1B基因多态性与COPD的易感性有人种差异;在高加索人中,IL-1B-511C/T的T等位基因与COPD发病风险呈正相关,IL-1B-31T/C的C等位基因与COPD发病风险呈负相关. Objective To explore the association between the-511C/T,-31T/C and +3954C/T polymorphisms of interleukin-1B (IL-1 B) gene and chronic obstructive pulmonary disease (COPD) using the method of meta-analysis.Methods Comprehensive searches were performed of PubMed,Embase,Ovid,Wanfang and Chinese journal full-text database to retrieve the related case-control studies.The pooled odds ratios were performed respectively for allele comparison,additive genetic model,dominant genetic model and recessive genetic model and subgroup analysis was also performed by ethnicity.Results Seven case-control studies were included for meta-analysis.Pooled analysis showed that neither-511C/T,-31T/C nor + 3954 C/T polymorphisms increased the susceptibility to COPD.In the subgroup analysis by ethnicity,significant risks were found in the Caucasian population for-511C/T T allele (OR =1.76,95%CI 1.22-2.54,P =0.002),but not in the Asian population(OR =0.94,95% CI 0.64-1.38,P =0.736).Significant risks were also found in the Caucasian population for-31T/C C allele (OR =0.62,95% CI 0.40-0.97,P =0.035),but not in the Asian population (OR =1.06,95% CI 0.89-1.26,P =0.533).Conclusions IL-1B polymorphisms may play a role in the susceptibility of COPD in an ethnicityspecific manner.In the Caucasian population,the risk of COPD was associated positively with the IL-1B -511C/T T allele and negatively with the IL-1B-31T/C C allele.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/71040
Appears in Collections:北京大学第三临床医学院_呼吸内科_期刊论文

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作者单位: 100191,北京大学第三医院呼吸科

Recommended Citation:
梅静静,梁瀛,沈宁,等. 白细胞介素1B基因多态性与慢性阻塞性肺疾病关系的荟萃分析[J]. 中华医学杂志,2013,93(12):910-915.
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