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学科主题: 呼吸内科学
题名:
北京市大气污染物对慢性阻塞性肺疾病预后的影响
其他题名: Association between particulate air pollution and the prognosis of chronic obstructive pulmonary disease in Beijing
作者: 朱瑞霞; 陈亚红; 邓芙蓉; 吴少伟; 姚婉贞
关键词: 大气污染物 ; 慢性阻塞性肺疾病 ; Air pollutants ; Chronic obstructive pulmonary disease
刊名: 国际呼吸杂志
发表日期: 2012
DOI: 10.3760/cma.j.issn.1673-436X.2012.009.005
卷: 32, 期:9, 页:665-671
收录类别: 中国科技核心期刊
文章类型: Journal Article
摘要: 目的 探讨大气污染物与慢性阻塞性肺疾病(COPD)预后的相关关系,并明确何种大气污染物与COPD最相关.方法 COPD患者的资料由北京大学第三医院病案室提供.包括COPD患者的基本信息和预后指标:入院人数,死亡人数和急性发作次数.大气污染物和气象资料由中国科学院大气物理所提供.在控制气温,气压和相对湿度下,采用广义相加模型(GAM)分析,用样条平滑函数拟合非线性变量,分析大气污染物与COPD预后指标的相关关系.结果 在单污染物模型中,PM10与COPD入院人数呈正相关,并且PM10每升高一个IQR(55.89 μg/m3),COPD入院人数增加29.69% (95% CI7.89%~55.88%).SO2和NO2与COPD死亡人数分别呈正、负相关.SO2每升高一个IQR( 48.58μg/m3),COPD死亡人数增加64.51%(14.11%~137.14%),而NO2每升高一个IQR(20.97 μg/m3)COPD死亡人数减少35.25%(-54.32%~-8.19%).在双污染物模型中,经过组合,PM10与COPD入院人数和死亡人数均呈正相关,PM10每升高一个IQR,COPD入院人数和死亡人数分别增加28.85%(95% CI6.29%~55.31%)和46.35%(11.42%~92.26%).而对于SO2和NO2组合,SO2和NO2每升高一个IQR,COPD死亡人数分别增加125.01% (61.25%~213.98%)和减少61.53% (-66.03%~-32.83%).无论在单污染物模型还是双污染物模型COPD急性加重与大气污染物未发现任何相关.结论 大气污染物会影响COPD的入院人数和死亡人数,导致COPD发病率和病死率增加,而PM10是主要的危险因子. Objective This study was undertaken to determined whether there is an association between air pollutants and hospital admissions,mortality and acute exacerbations for chronic obstructive pulmonary disease (COPD) in Beijing and identified which pollutants contributed most to this effect.Methods Data of patients for COPD were obtained from Perking University Third Hospital,includingbasic information and the prognosis such as hospital admissions,mortality and acute exacerbations for COPD.The air pollutants and meteorological data were collected from Institute of Atmospheric Physics,Chinese Academy of Science.We analyzed monthly hospital admissions,mortality and acute exacerbations for COPD and air pollutants data using Poisson regression in generalized additive models (GAM),adjust for the mean temperature,pressure and relative humidity.Results Significant associations were found between hospital admissions and mortality for COPD with these pollutants.In the single-pollutant model,an interquartile range (IQR) change of PM10 was associated with a 29.69% (7.89% to 55.88%) increase in hospital admissions for COPD.An IQR change of SO2 and NO2 were associated with a 64.51%(14.11% to 137.14%) increase and a 35.25% (-54.32% to -8.19%) decrease in COPD mortality respectively.While in the multiple-pollutant model,an IQR change of PM10 and NO2 were associated with a 46.35 % ( 11.42 % to 92.26 %) increase and a 52.91 % ( - 68.72 % to - 29.12 %) decrease in COPD mortality.And SO2 and NO2 were associated with a 125.01% (61.25% to 213.98%) increase and a 61.53% (-66.03% to -32.83%) decrease in COPD mortality.Conclusions Ambient concentrations of pollutants have an adverse effect on hospital admissions and mortality for COPD in Beijing and PM10contributed most to COPD prognosis.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/71066
Appears in Collections:北京大学第三临床医学院_呼吸内科_期刊论文

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作者单位: 1.100191,北京大学第三医院呼吸科
2.100191,北京大学公共卫生学院劳动卫生与环境学系

Recommended Citation:
朱瑞霞,陈亚红,邓芙蓉,等. 北京市大气污染物对慢性阻塞性肺疾病预后的影响[J]. 国际呼吸杂志,2012,32(9):665-671.
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