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学科主题: 呼吸内科学
题名:
选择性β1受体阻滞剂对慢性阻塞性肺疾病合并心血管疾病患者肺功能的影响——Meta分析
其他题名: Effect of cardioselective β1-blockers on airway function in the chronic obstructive pulmonary disease patients with cardiovascular diseases: meta analysis
作者: 梁瀛; 苏健; 贺蓓
关键词: 选择性β1受体阻滞剂 ; 慢性阻塞性肺疾病 ; 肺功能 ; Meta分析 ; Selective β1-blockers ; Chronic obstructive pulmonary disease ; Pulmonary function ; Meta analysis
刊名: 国际呼吸杂志
发表日期: 2011
DOI: 10.3760/cma.j.issn.1673-436X.2011.017.003
卷: 31, 期:17, 页:1290-1294
收录类别: 中国科技核心期刊
文章类型: Journal Article
摘要: 目的综合评价心脏选择性β1受体阻滞剂对慢性阻塞性肺疾病(COPD)合并心血管疾病患者肺功能的影响,为临床医师应用β1受体阻滞剂提供参考依据。方法 制定文献纳入标准及检索策略,计算机检索中国期刊全文数据库及PubMed数据库,不限定发表年限,收集公开发表的、研究COPD合并心血管疾病(包括高血压、冠状动脉粥样硬化性心脏病或慢性心力衰竭)患者应用β1受体阻滞剂前后肺功能第1秒用力呼吸容积(FEV1)占预计值百分比变化的文献,包括随机对照研究及无对照药物疗效观察,应用STATA 9.2软件进行Meta分析。结果共8篇文献符合纳入标准,其中4篇为随机对照研究(包括交叉设计随机对照研究),另外4篇为无对照药物疗效观察。对4篇随机对照研究经荟萃分析后结果显示,使用β1受体阻滞剂后FEV1占预计值百分比较用药前差异无统计学意[(SMD=-0.082,95% CI(-0.757,0.592),P=0.811];而对另外4篇无对照药物疗效观察经荟萃分析后亦得到类似的结果[SMD=0.142,95% CI(-0.062,0.346),P=0.171]。提取随机对照研究中试验组的数据与无对照药物疗效观察的数据进行荟萃分析,仍未发现β1受体阻滞剂对FEV1占预计值百分比产生显著影响[SMD=0.057,95%CI(-0.212,0.325),P=0.679]。结论 心脏选择性β1受体阻滞剂不显著降低COPD合并心血管疾病患者的肺功能。 Objective To evaluate the effect of cardioselective β1-blockers on airway function in the chronic obstructive pulmonary disease (COPD) patients with cardiovascular diseases and provide some reference information for clinical physicians. Methods Comprehensive searches about the effect of β1-blockers on airway function in the COPD patients with cardiovascular diseases including hypertension,coronary heart disease or heart failure were performed of the chinese journal full-text database and PubMed database. Random controlled trials and drug observations without control were included and strictly screened according to inclusion criteria. STATA 9.2 programme was used for meta analysis.Results Eight studies were included, involving four random controlled trials (one cross-over trial) and four drug observations. Pooled analysis for the random controlled trials showed that FEV1 as percent of normal predicted value (FEV1 % pred) did not change significantly after given β1-blockers compared to before (SMD=0.082,95% CI (-0.757,0.592), P =0.811), and so as for the drug observations (SMD=0.142,95% CI (-0.062,0.346), P =0.171). Furthermore, the result was not changed after combining the data of the trial groups in the random controlled trials and the groups in the drug observations (SMD =0.057, 95% CI (-0.212, 0.325), P =0.679). Conclusions Cardioselective β1-blockers given to the COPD patients with cardiovascular diseases do not produce a significant reduction
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/71080
Appears in Collections:北京大学第三临床医学院_呼吸内科_期刊论文

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作者单位: 1.100191,北京大学第三医院呼吸内科
2.江苏省疾病预防疾控中心, 南京,210009

Recommended Citation:
梁瀛,苏健,贺蓓. 选择性β1受体阻滞剂对慢性阻塞性肺疾病合并心血管疾病患者肺功能的影响——Meta分析[J]. 国际呼吸杂志,2011,31(17):1290-1294.
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