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学科主题: 呼吸内科学
题名:
氯酚伪麻缓释片治疗普通感冒和流行性感冒的疗效和安全性
其他题名: Efficacy and safety of loratadine paracetamol and pseudoephedrine sustained release tablets in the treatment of common cold and influenza
作者: 陈亚红; 姚婉贞; 王广发; 曹照龙; 林江涛; 陈良安
关键词: 氯酚伪麻缓释片 ; 双扑伪麻 ; 普通感冒 ; 流行性感冒 ; loratadine paracetamol and pseudoephedrine sustained-re-lease tablets ; compound pseudoephedrine hydrochloride ; common cold ; influenza
刊名: 中国临床药理学杂志
发表日期: 2010
DOI: 10.3969/j.issn.1001-6821.2010.02.002
卷: 26, 期:2, 页:89-92
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的 评价氯酚伪麻缓释片(抗感冒药)治疗普通感冒和流行性感冒的安全性和有效性.方法 用多中心、随机、双盲、平行对照临床试验,试验组(n=118)给予氯酚伪麻缓释片,对照组(n=119)给予双扑伪麻片.结果 试验组的临床症状改善率不低于对照组(P<0.05),试验前后2组临床症状总积分均无明显差别(P>0.05);试验组和对照组的总有效率分别为96.33%和96.36%(P>0.05).试验组和对照组的药物不良反应发生率分别为7.02%和11.82%(P>0.05).结论 氯酚伪麻缓释片治疗普通感冒和流行性感冒具有明显疗效和安全性. Objective To evaluate the efficacy and safety of the loratadine paracetamol and pseudoephedrine(LPP)sustained-release tablets in the treatment of common cold and influenza compared with compound pseudoephedrine hydrochloride tablets.Methods Multi-center,randomized,double-blinded controlled clinical trial.One hundred eighteen patients were given LPP sustained-release tablets as trial group,119 were given pseudoephedrine hydrochloride as control group.Results Non-inferiority statistics showed that the improvement rate of clinical symptoms in trial group were not lower than that in control group(P<0.05).The total symptom score did not differ in trial group and control group(P>0.05).The effective rate in trial group and control group were 96.33% and 96.36%(P>0.05).The incidence of adverse drug reactions in trial group and control group was 7.02% and 11.82%,respectively(P>0.05).Conclusion LPP sustained-release tablets is effective and safe in the treatment of common cold and influenza.
语种: 中文
原文出处: 查看原文
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/71263
Appears in Collections:北京大学第三临床医学院_呼吸内科_期刊论文

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作者单位: 1.北京大学第三医院呼吸科,北京,100191
2.北京大学第一医院,北京,100034
3.北京大学人民医院,北京,100044
4.北京中日友好医院,北京,100029
5.中国人民解放军总医院,北京,100853

Recommended Citation:
陈亚红,姚婉贞,王广发,等. 氯酚伪麻缓释片治疗普通感冒和流行性感冒的疗效和安全性[J]. 中国临床药理学杂志,2010,26(2):89-92.
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