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其他题名Changes of anaphylatoxin C5a in chronic obstructive pulmonary disease and the relationship with systemic and local inflammation
张静; 姚婉贞; 孙永昌
关键词肺疾病,慢性阻塞性 过敏毒素类 炎症 Pulmonary disease,chronic obstructive Anaphylatoxins Inflammation
收录类别中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型Journal Article
摘要目的 探讨过敏毒素C5a在COPD发病中的作用.方法 2006年9月至2007年2月在北京大学第三医院门诊的COPD患者64例(其中COPD急性加重期组31例、COPD稳定期组33例)和健康对照组15名.测定肺功能,对诱导痰进行炎症细胞分类计数、ELISA法测定诱导痰上清液及血中过敏毒素C5a、诱导痰上清液中白细胞介素-8(IL-8)水平,免疫比浊法测定血中超敏C反应蛋白(hs-CRP)水平.计量资料中非正态分布的数据两组问比较采用Mann-Whitney u检验,多组间比较采用Kruskal-Wallis检验;正态分布的数据两组间比较采用t检验,多组间比较采用单因素方差分析.计数资料多组间比较采用x2检验.各组变量间的相关性采用Spearman相关分析.结果 COPD急性加重期患者血清CSa水平[215(109~376)μg/L]较稳定期COPD患者明显升高[91(53~365)μg/L],且升高程度与hs-CRP正相关(r=0.574,P<0.05),与FEV1占预计值%负相关(r=-0.562,P<0.05).COPD急性加重期患者诱导痰中C5a水平[1.8(1.0~3.2)μg/L]明显高于稳定期患者[0.9(0.2~2.4)μg/L],与诱导痰中IL-8水平呈正相关(r=0.518,P<0.05);COPD稳定期患者诱导痰中C5a水平明显高于健康对照组[0.3(0.1~0.7)μg/L].COPD急性加重期患者中诱导痰中C5a水平与细胞总数呈正相关(r=0.441,P<0.05),与中性粒细胞绝对值呈正相关(r=0.439,P<0.05),与单核巨噬细胞绝对值呈正相关(r=0.449,P<0.05).结论 C5a可能参与COPD全身炎症反应和气道炎症的发牛和发展. Objective To investigate the role of anaphylatoxin C5a in the pathogenesis of chronic obstructive pulmonary disease(COPD).Methods A total of 64 elderly patients with COPD(31 acute exacerbation of COPD,34 stable COPD)and 15 healthy subjects were recruited into the study.Lung function,the levels of serum C5a and high sensitivity CRP(hs-CRP),and the levels of C5a,IL-8 and cell differentials in induced sputum were determined.For nonnormally distributed vailables,differences between two groups wore analysed using a Mann-Whitney u test,and comparison of three groups was performed using analysis of Kruskal-Wallis test.For normally distributed variables,differenees between two groups were analyzed using unpaired t test,and comparison of three groups was performed using analysis of one-way ANOVA.Comparisons of the groups were performed using Chi-squared test for enumeration data.The association between variables was assessed by Spearman rank-order method.Results The levels of serum C5a in acute exacerbation of COPD[215(109-376)μg/L]were higher than those in stable COPD[91(53-365)μg/L,z=-2.123,P<0.05],and were positively correlated with the level of serum hs-CRP (r=0.574,P<0.05),and negatively correlated with FEV1%predicted(r=-0.562,P<0.05).The levels of C5a in induced sputum in acute exacerbation of COPD[1.8(1.0-3.2)μg/L]were significantly higher than those in stable COPD[0.9(0.2-2.4)μg/L,x=-2.079,P<0.05]and were positively correlated with the level of IL-8 in induced sputum(r=0.518,P<0.05).The levels of C5a in induced sputum in stable COPD were significantly higher than those in healthy subjects[0.3(0.1-0.7)μg/L,z=-2.044.P<0.05 ].The level of C5a in induced sputum was positively correlated with the number of total cells count(r=0.441,P<0.05),the percentage of neutrophils(r=0.439,P<0.05)and macrophages(r=0.449,P<0.05)in acute exacerbation of COPD.Conclusion Anaphylatoxin(C5a)may be involved in the pathogenesis of COPD.
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张静,姚婉贞,孙永昌. 慢性阻塞性肺疾病过敏毒素C5a的变化及其与炎症反应的关系[J]. 中华结核和呼吸杂志,2008,31(5):356-359.
APA 张静,姚婉贞,&孙永昌.(2008).慢性阻塞性肺疾病过敏毒素C5a的变化及其与炎症反应的关系.中华结核和呼吸杂志,31(5),356-359.
MLA 张静,et al."慢性阻塞性肺疾病过敏毒素C5a的变化及其与炎症反应的关系".中华结核和呼吸杂志 31.5(2008):356-359.
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