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学科主题: 急诊医学
题名:
因慢性阻塞性肺疾病急性加重频繁住院患者的病原学特征
其他题名: Bacteriology in acute exacerbation in patients hospitalized frequently for acute exacerbation of chronic obstructive pulmonary disease
作者: 郭治国; 常春; 陈亚红; 郑亚安; 姚婉贞
关键词: 肺疾病,慢性阻塞性 ; 疾病恶化 ; 住院病人 ; 病原 ; Pulmonary disease,chronic obstructive ; Disease progression ; Inpatients ; Noxae
刊名: 中华医学杂志
发表日期: 2014
DOI: 10.3760/cma.j.issn.0376-2491.2014.10.003
卷: 94, 期:10, 页:729-732
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的 分析因慢性阻塞性肺疾病急性加重(AECOPD)而频繁住院患者的病原学特征.方法 自2007年1月至2008年12月在北京大学第三医院住院的AECOPD患者,病历明确记载AECOPD住院次数者入选.记录患者急性加重时的病原学分布、多重耐药菌感染情况.根据过去一年中因AECOPD而住院的次数把患者分为频繁住院组(住院次数≥2次)和非频繁住院组(住院次数<2次);比较2组病原菌分布及耐药情况.结果 共172例患者获得完整资料,其中男134例;女48例.第1秒用力呼气量占预计值百分比为35% (28% ~45%).住院前1年因AECOPD住院情况:76例(44.2%)未因AECOPD住院;48例(27.9%)有1次因AECOPD住院;48例(27.9%)有2次因AECOPD住院.与非频繁住院组相比,频繁住院组患者更多地分离到非发酵革兰阴性菌[18.8%(9/48)比4.8% (6/124),x2=6.756,P=0.009]、肠杆菌科细菌[18.8% (9/48)比7.3% (9/124),x2=4.877,P=0.027].频繁住院组多重耐药菌检出率显著高于非频繁住院组[25.0%(12/48)比8.1%(10/124),x2=8.898,P=0.003].结论 AECOPD患者感染细菌种类与AECOPD住院次数相关. Objective To analyze the distribution of pathogens and bacterial drug resistance for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in patients hospitalized frequently for AECOPD versus those with infrequent admissions.Methods A total of 172 patients admitted into Peking University Third Hospital for AECOPD from January 2007 to December 2008 were recruited.According to the frequency of AECOPD-related hospitalization during the previous year,they were divided into two groups of frequently hospitalized (≥2 hospitalizations due to AECOPD during the previous year) and infrequently hospitalized (< 2 hospitalizations due to AECOPD during the previous year).The distribution and drug resistance of pathogenic bacteria were compared between two groups.Results At the time of acute exacerbation,the frequently hospitalized patients had significantly higher rates of nonfermentative gram-negative bacteria (18.8% (9/48) vs 4.8% (6/124),x2 =6.756,P =0.009),enterobacteriaceae (18.8% (9/48) vs 7.3% (9/124),x2 =4.877,P =0.027) versus those infrequently hospitalized ones.The frequently hospitalized patients had more muhidrug resistant bacteria isolated from sputum versus those infrequently hospitalized ones (25.0% (12/48) 比 8.1% (10/124),x2 =8.898,P =0.003).Conclusion The distribution and drug resistance of pathogenic bacteria are associated with the frequency of AECOPD-related hospitalization during the previous year.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/71416
Appears in Collections:北京大学第三临床医学院_急诊科_期刊论文

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作者单位: 1.100191,北京大学第三医院急诊科
2.100191,北京大学第三医院呼吸科

Recommended Citation:
郭治国,常春,陈亚红,等. 因慢性阻塞性肺疾病急性加重频繁住院患者的病原学特征[J]. 中华医学杂志,2014,94(10):729-732.
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