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学科主题急诊医学
脓毒症患者降钙素原与APACHEⅡ评分的相关性探讨
其他题名The relationship between serum procalcitonin (PCT) level and acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ ) score in septic patients
刘慧琳; 刘桂花
关键词降钙素原 脓毒症 急性生理学与慢性健康状况Ⅱ评分 Procalcitonin Sepsis Acute physiology and chronic health evaluation Ⅱ
刊名中华急诊医学杂志
2012
DOI10.3760/cma.j.issn.1671-0282.2012.04.009
21期:4页:371-374
收录类别中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型Journal Article
摘要目的 探讨脓毒症患者血清降钙素原(PCT)与急性生理学与慢性健康状况Ⅱ(APACHEⅡ)评分及预后的关系,进而了解PCT对脓毒症早期诊断和预后的影响.方法 采用前瞻性方法进行研究,将北京大学第三医院急诊重症监护病房(EICU)脓毒症90例患者按照APACHEⅡ评分分组,测定患者入院后24h内PCT、超敏C反应蛋白(hs-CRP)及乳酸的水平,比较PCT、白细胞和乳酸的差异.后再根据患者28 d结局不同(分为生存组和死亡组两组),比较PCT、APACHEⅡ评分、白细胞及乳酸的差异.结果 低危组患者PCT为(0.15±0.14) ng/ml,低于中危组(0.62±0.61) ng/ml和高危组(5.32±5.20) ng/ml,中危组PCT低于高危组,其差异均具有统计学意义(P<0.01).死亡组PCT和APACHEⅡ评分明显高于生存组,差异具有统计学意义(P<0.01);死亡组的白细胞和乳酸高于生存组,差异具有统计学意义(P<0.05),但PCT和APACHEⅡ评分更为明显.结论 PCT与APACHEⅡ评分具有较好的相关性;联合PCT检测和APACHEⅡ评分是预测脓毒症预后较为敏感的指标. Objective To investigate the relationships between serum procalcitonin (PCT) level and APACHE Ⅱ score as well the prognosis of septic patients.Methods Ninety patients with sepsis were collected from emergency and critical care department of Third Hospital,Peking University,Beijing.Within 24 hours after admission,the serum PCT,hypersensitive C-reactive protein (hs-CRP),leucocyte count (WBC) and lactic acid were examined,and APACHE Ⅱ score were calculated.According to APACHE Ⅱscore,the septic patients were divided into three groups of high,median and low scores.Based on the 28 -day outcomes of patients,the patients were divided into survival group and death group.The differences in PCT,APACHE score,WBC and lactic acid between the survival group and the death group were detected.Results The serum levels of PCT were significantly higher ( P < 0.01 ) in patients with high APACHE Ⅱ score ( > 20) than that in patients with median score (10-20) and low score ( < 10 ).There was significant correlation between PCT level and APACHE Ⅱscore ( r =0.58,P <0.01 ).Conclusions There is a good correlation between serum PCT level and APACHE Ⅱ score.The serum PCT and APACHE Ⅱ can be used for predicting the outcomes of septic patients.
语种中文
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文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/71429
专题北京大学第三临床医学院_急诊科
作者单位北京大学第三医院急诊科, 北京,100191
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刘慧琳,刘桂花. 脓毒症患者降钙素原与APACHEⅡ评分的相关性探讨[J]. 中华急诊医学杂志,2012,21(4):371-374.
APA 刘慧琳,&刘桂花.(2012).脓毒症患者降钙素原与APACHEⅡ评分的相关性探讨.中华急诊医学杂志,21(4),371-374.
MLA 刘慧琳,et al."脓毒症患者降钙素原与APACHEⅡ评分的相关性探讨".中华急诊医学杂志 21.4(2012):371-374.
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