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学科主题: 临床检验诊断学
题名:
健康人群血清HE4水平参考区间的初步探讨
其他题名: Investigation on the reference range of human serum levels of human epididymis protein 4 hi healthy people
作者: 胡晓舟; 崔丽艳; 张捷
关键词: 附睾分泌蛋白质类 ; 肿瘤标记 ; 生物学 ; 参考值 ; Epididymis secretory protein ; Tumor markers ; biological ; Reference values
刊名: 中华检验医学杂志
发表日期: 2009
DOI: 10.3760/cma.j.issn.1009-9158.2009.12.011
卷: 32, 期:12, 页:1376-1378
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的 对健康人群血清人附睾上皮分泌蛋白4(human epididymis protein 4,HE4)水平参考区间的初步探讨.方法 采用ELISA法测定530名健康体检成人及非肿瘤患者血清HE4水平,分析年龄、性别、绝经以及良性疾病对其影响,建立中国北方人群血清HE4水平的参考区间.结果 血清HE4水平随着年龄增加而升高,二者显著相关(r=0.473,P<0.01).男性>50岁组血清HE4水平为(56.6±22.6)pmol/L,明显高于≤50岁组的(32.9±15.2)pmoL/L;女性>40岁组血清HE4水平为(41.6±10.4)pmol/L,明显高于≤40岁组的(32.8±13.4)pmol/L.相应年龄阶段良性疾病组血清HE4水平均高于健康人群组.以(x)+2s为参考上限,男性参考区间为≤50岁<63.3 pmoL/L,>50岁<101.8 pmol/L;女性参考区间≤40岁<59.6 pmol/L,>40岁<62.4 pmol/L.结论 年龄及疾病是影响人血清HE4水平的重要生理因素,应根据不同年龄分别建立血清HE4水平的参考区间. Objective To investigate the reference range of serum human epididymis protein 4 ( HE4 ) . Methods An Enzyme-linked immunosorbent assay ( ELISA) was used to measure the concentrations of HE4. Totally 530 cases of healthy adults and benign disease patients were determined . The impact of age, sex, menopause status and diseases on serum HE4 levels was analyzed. Then the reference range was established in the north of China Results The serum HE4 levels had a positive correlation with age (r=0. 473,P<0. 01). The serum levels of HE4 in the group of the male age≤50 years[ (56. 6 ±22. 6) pmol/L]is lower than that in the male age >50 years[ (32. 9 ± 15. 2) pmol/L]. The serum levels of HE4 in the group of female age≤40 years [ (41. 6 ± 10. 4) pmol/L] is lower than that in the group of the female age >40 years[(32. 8 ±13.4) pmol/L]. Serum level of HE4 was higher in benign disease group as compared with that in health group in both gender and all age groups. The upper and 101. 8 pmol/L respectively. The upper limit of reference range for female in the groups of age≤40 years and age > 40 years is 59. 6 pmol/L and 62.4 pmol/L respectively. Conclusions Age and disorder are two important factors which can affect human serum level of HE4. The age should take into consideration for establishment of HE4 reference range.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/71571
Appears in Collections:北京大学第三临床医学院_检验科_期刊论文

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作者单位: 北京大学第三医院检验科,100191

Recommended Citation:
胡晓舟,崔丽艳,张捷. 健康人群血清HE4水平参考区间的初步探讨[J]. 中华检验医学杂志,2009,32(12):1376-1378.
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