IR@PKUHSC  > 北京大学第三临床医学院  > 介入血管外科
学科主题血管外科学
急性高危肺栓塞介入取栓、溶栓中应用 r-tPA 与尿激酶溶栓时间及疗效比较
其他题名Comparison of curative effect and thrombolysis time between r-tPA application and urokinase in the interventional thrombectomy and thrombolysis for acute and severe pulmonary embolism
冯琦琛; 李选; 董国祥; 傅军; 王昌明
关键词肺栓塞 血栓溶解疗法 血管内手术 组织型纤溶酶原激活物 尿纤溶酶原激活物 Pulmonary embolism Thrombolytic therapy Endovascular procedures Tissue plasmino-gen activator Urokinase-type plasminogen activator
刊名北京大学学报(医学版)
2014
DOI10.3969/j.issn.1671-167X.2014.03.023
3页:460-463
文章类型Journal Article
摘要目的:探讨急性高危型肺栓塞患者经介入取栓后,应用r-tPA和尿激酶行介入溶栓治疗,对疗效和溶栓时间的影响。方法:回顾性分析19例急性高危型肺栓塞患者的临床资料,根据其应用r-tPA或尿激酶行介入溶栓分为两组,比较两组间溶栓前后心率、血压、肺动脉压、动脉血氧分压和血红蛋白的变化,以及两组的溶栓时间。结果:各组患者术前和术后心率、血压、动脉血氧分压均有明显改善(P<0.05);应用r-tPA组患者术后肺动脉压较术前有所降低,但差异无统计学意义(P>0.05),应用尿激酶组患者术后肺动脉压较术前显著降低(P<0.05)。两组患者术后血红蛋白均未出现明显降低( P>0.05);应用r-tPA组患者溶栓时间明显短于应用尿激酶组患者( P<0.05)。结论:应用r-tPA与尿激酶行急性高危型肺栓塞的介入溶栓治疗均有效,但应用r-tPA能够显著缩短溶栓时间,且不增加出血风险。 Objective:To study the influence of r-tPA and urokinase in curative effect and thrombolysis time on patients with acute and severe pulmonary embolism after interventional thrombectomy .Methods:After reviewing and analyzing the clinical data of 19 acute and severe pulmonary embolism patients , we classified them into two groups in accordance with the application of r-tPA and urokinase to compare the changes of their heart rate , blood pressure , pulmonary arterial pressure , arterial partial pressure of oxygen and hemachrome before and after thrombolysis , as well as the thrombolysis effect time the two groups took.Results: The heart rate, blood pressure, pulmonary arterial pressure , arterial partial pressure of oxygen of the patients in both groups gained remarkable improvement after operation ( P<0 .05 );the pulmonary arterial pressure of the r-tPA patient group dropped but not significantly compared with that before operation ( P>0.05); the pulmonary arterial pressure of the urokinase patient group dropped significantly compared with that study before operation ( P<0.05 ); the hemachrome of both patient groups did not significantly drop after operation ( P>0 .05 );the thrombolysis effect time by adop-ting r-tPA was remarkably shorter than that caused in thrombolysis by adopting urokinase ( P<0 .05 ) . Conclusion: Both r-tPA and urokinase are effective in interventional thrombolysis for acute and severe pulmonary embolism .However , r-tPA could significantly shorten the time caused in thrombolysis without increasing any bleeding risk.
语种中文
原文出处查看原文
Citation statistics
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/71751
Collection北京大学第三临床医学院_介入血管外科
作者单位北京大学第三医院介入血管外科,北京,100191
Recommended Citation
GB/T 7714
冯琦琛,李选,董国祥,等. 急性高危肺栓塞介入取栓、溶栓中应用 r-tPA 与尿激酶溶栓时间及疗效比较[J]. 北京大学学报(医学版),2014(3):460-463.
APA 冯琦琛,李选,董国祥,傅军,&王昌明.(2014).急性高危肺栓塞介入取栓、溶栓中应用 r-tPA 与尿激酶溶栓时间及疗效比较.北京大学学报(医学版)(3),460-463.
MLA 冯琦琛,et al."急性高危肺栓塞介入取栓、溶栓中应用 r-tPA 与尿激酶溶栓时间及疗效比较".北京大学学报(医学版) .3(2014):460-463.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[冯琦琛]'s Articles
[李选]'s Articles
[董国祥]'s Articles
百度学术
百度学术Similar articles in
[冯琦琛]'s Articles
[李选]'s Articles
[董国祥]'s Articles
必应学术
必应学术Similar articles in
[冯琦琛]'s Articles
[李选]'s Articles
[董国祥]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.