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IR@PKUHSC  > 北京大学第三临床医学院  > 老年内科  > 期刊论文
学科主题: 老年医学
题名:
长期应用非那雄胺治疗良性前列腺增生临床疗效分析
其他题名: Clinical effects of long-term use of finasteride in treatment of patients with benign prostatic hyperplasia
作者: 姜玲; 朱昀
关键词: 前列腺增生 ; 药物疗法 ; Prostatic hyperplasia ; Drug therapy
刊名: 中华老年医学杂志
发表日期: 2011
DOI: 10.3760/cma.j.issn.0254-9026.2011.11.008
卷: 30, 期:11, 页:924-925
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的 探讨长期应用非那雄胺治疗良性前列腺增生(BPH)的临床疗效及安全性.方法 观察患有BPH并坚持服用非那雄胺5 mg/d治疗7年以上的患者并分析其临床资料.结果 患者治疗前后前列腺体积分别为(48.0±12.5)ml和(41.0±8.4) ml,治疗后前列腺体积明显缩小(t=2.04,P<0.05).血清前列腺特异抗原(PSA)治疗前后分别为(3.8±1.5)μg/L和(1.5±1.1)μg/L,差异有统计学意义(t=5.30,P<0.05),治疗后2倍PSA值为(2.9±2.2)μg/L,较治疗前差异无统计学意义(t=1.38,P>0.05).国际前列腺症状评分(IPSS)治疗后有显著改善[(21.1±7.0)分与(17.1±4.5)分,t=2.09,P<0.05].治疗期间1例患者发生急性尿潴留,1例患者出现肉眼血尿,未见其他不良反应.结论 长期应用非那雄胺治疗良性BPH疗效好,不良反应小,值得临床推广. Objective To evaluate the clinical efficacy and safety of long-term use of finasteride in the treatment of patients with benign prostatic hyperplasia(BPH).Methods The clinical data of patients with BPH receiving finasteride 5 mg daily for more than 7 years were analyzed.Results The prostate volumes were significantly reduced from (48.0 ± 12.5) ml before treatment to (41.0 ±8.4)ml after treatment (t = 2.04,P< 0.05 ).The serum levels of prostatic specific antigen (PSA)were (3.8 ± 1.5) μg/L and ( 1.5 ± 1.1 ) μtg/L before and after treatment,respectively(t = 5.30,P<0.05),but 2 times in PSA post-treatment were (2.9 ± 2.2) μg/L with no difference versus pretreatment (t= 1.38,P> 0.05).International prostate symptome score (IPSS) after treatment (17.1±4.5) was significantly improved as compared with pre-treatment (21.1 ± 7.0) (t = 2.09,P<0.05).1 case with acute urinary retention and 1 case with hematuria occurred and no other side effects were found during treatment.Conclusions Long-term use of finasteride for the treatment of BPH is effective,safe and worthy of wide use.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/72039
Appears in Collections:北京大学第三临床医学院_老年内科_期刊论文

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作者单位: 100191,北京大学第三医院老年内科

Recommended Citation:
姜玲,朱昀. 长期应用非那雄胺治疗良性前列腺增生临床疗效分析[J]. 中华老年医学杂志,2011,30(11):924-925.
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