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IR@PKUHSC  > 北京大学第三临床医学院  > 麻醉科  > 期刊论文
学科主题: 麻醉学
题名:
脊柱手术患者术后谵妄和术后认知功能障碍的危险因素
其他题名: Risk factors for post-operative delirium and post-operative cognitive dysfunction in patients undergoing spine surgery
作者: 倪诚; 贾东林; 许挺; 李楠; 李岩; 王军; 李民; 郭向阳
关键词: 执行功能 ; 抑郁 ; 危险因素 ; 谵妄 ; 认知障碍 ; 手术后并发症 ; Executive function ; Depression ; Risk factors ; Delirium ; Cognition disordcrs ; Postoperative complications
刊名: 中华麻醉学杂志
发表日期: 2012
DOI: 10.3760/cma.j.issn.0254-1416.2012.05.006
卷: 32, 期:5, 页:541-544
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的 筛选脊柱手术患者术后谵妄(POD)和术后认知功能障碍(POCD)的危险因素.方法 择期全麻下行脊柱手术的患者120例,性别不限,年龄50~76岁.根据术后2d是否发生POD,将患者分为非POD组和POD组,根据术后3d是否发生POCD,将患者分为非POCD组和POCD组.术前1d分别采用Stroop色词测验和Beck抑郁自评量表评估执行功能和抑郁状态,记录年龄、性别、受教育程度、每周饮酒量、精神病史、ASA分级和Charlson合并症指数、麻醉方法和术中抗胆碱能药物使用情况、术后1d时VAS评分,将组间差异有统计学意义的因素进行多因素logistic回归分析,筛选POD和POCD的危险因素.结果 11例患者发生POD,发生率9.2%;30例患者发生POCD,发生率25.0%.logistic同归分析结果显示:Stroop评分低、Beck抑郁评分高、Charlson合并症指数高和精神病史是POD的危险因素;Stroop评分低、Beck抑郁评分高、Charlson合并症指数高和每周饮酒量多是POCD的危险因素(p<0.05或0.01).结论 术前执行功能降低、抑郁状态和合并症多是脊柱手术患者POD和POCD共同的危险因素,精神病史是POD的危险因素,饮酒量多是POCD的危险因素. Objective To determine the risk factors for post-operative delirium(POD)and post-operative cognitive dysfunction(POCD)in patients undergoing spine surgery.Methods One hundred and twenty ASA Ⅰ-Ⅲ of both sexes aged 50-76 yr undergoing elective spine surgery under general anesthesia were studied.POD was assessed by Delirium Rating Scale revised 98 at 2 days after operation and the patients were assigned into POD and nonPOD group.Cognitive function was assessed by Mini-Mental State Examination(MMSE)at 1 day before and 3 days after operation.The patients were diagnosed as having POCD if MMSEpre-MMSEpost ≥ 3.The palients were assigned into POCD and nonPOCD group.Executive function and depression were assessed by stroop interference test and Beck Depression Inventory(BDI)at 1 day before operation.Age,sex,education,alcohol consumption per week,a history of psychiatric disease,ASA physical status,Charlson comorbidity score,type of anesthesia,anticholinergic drug administration and VAS score at 1 day after operation were recorded.If there was signifirant difference between the 2 groups,the factor was analyzed using multi-factor logistic regression to select risk factor for incidence of POD and POC).Results Eleven patients developed POD(9.2%)and 30 patients developed POCD(25.0%).Logistic regression model showed that lower Stroop-CW,higher BDI score,higher Charlson comorbidity score and a history of psychiatric disease were risk factors for POD,while lower Stroop-CW,higher BDI score,higher Charlson comorbidity score and higher alcohol consumption per week were risk factors for POCD.Conclusion Preoperative executive dysfunction,depression and greater preoperative comorbidity are risk factors for both POD and POCD.A history of psychiatric disease is a risk factor for POD and higher alcohol consumption is a risk factor for POCD in patients undergoing spine surgery.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/72169
Appears in Collections:北京大学第三临床医学院_麻醉科_期刊论文

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作者单位: 1.100191,北京大学第三医院麻醉科
2.临床流行病研究中心

Recommended Citation:
倪诚,贾东林,许挺,等. 脊柱手术患者术后谵妄和术后认知功能障碍的危险因素[J]. 中华麻醉学杂志,2012,32(5):541-544.
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