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右美托咪定对宫腹腔镜手术患者镇痛疗效与安全性的研究
其他题名Analgesia effects and safety of dexmedetomidine on patients undergoing combined hysteroscopy and laparoscopy
俞晨; 贾东林; 张小青; 孔丽娟; 李跃新; 杨艳; 王军
关键词右美托咪定 宫腹腔镜联合手术 镇静 镇痛 dexmedetomidine combined hysteroscopy and laparoscopy surgery sedation analgesia
刊名中国临床药理学杂志
2015
DOI10.13699/j.cnki.1001-6821.2015.02.003
2页:89-92
收录类别中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型Journal Article
摘要目的:评价右美托咪定在宫腹腔镜联合手术患者的镇痛疗效与安全性。方法90例行宫腹腔镜联合手术的患者随机分为3组:对照组(C组)、右美托咪定1组( D1组)和2组( D2组)。 D1、D2组,麻醉诱导后10 min,静脉泵入右美托咪定0.4μg· kg-1;C组给等量0.9%NaCl溶液。记录围术期循环指标、脑电双频谱指数(BIS)、手术时间、拔管时间,用视觉模拟评分法(VAS)评估手术后2,4,12,24 h的疼痛程度,并记录不良反应及镇痛药物使用情况。结果 D1、D2组循环指标较C组稳定,BIS值低于C组。 D1组拔管时间长于C组,D2组拔管时间与C组差异无统计学意义。 D1、D2组患者VAS低于C组,不良反应少,使用镇痛药物例数少。结论宫腹腔镜联合手术患者静脉泵注右美托咪定0.4μg· kg-1可节俭麻醉维持药物,不延长拔管时间,减轻术后疼痛,降低不良反应发生率,减少术后镇痛药物的用量。 Objective To investigate the effects of dexmedetomidine on patients undergoing combined hysteroscopy and laparoscopy . Methods Ninety patients undergoing combined hysteroscopy and lapa-roscopy were randomly divided into control group ( C ) , dexmedetomidine group1 ( D1 ) and dexmedetomidine group 2 ( D2 ) , with thirty patients each.Dexmedetomidine 0.4 μg · kg -1 was injected in each patient in group D1 and D2 intravenously in 10 min by infusing pump after induc-tion of anesthesia , while an equal volume of 0.9%NaCl was administered to patients in group C.Peri-operative mean arterial pressure (MAP), heart rate ( HR) , bispectral index ( BIS ) , operation time , and extuba-tion time were recorded.The intensity of pain was valued using visual analogue scale ( VAS) at 2, 4, 12, 24 h after operation.The adverse effects and the usage of analgesic drugs were recorded.Results Hemo-dynamic parameters were more stable during operation in group D 1 and D2 than those in group C , and BIS of group D1 and D2 were lower than that of group C.Extubation time of group D 1 was longer than that in group C , while there was no significant difference in extubation time be-tween group D2 and C.Compared with group C ,the data of VAS in group D1 and D2 were decreased , with less adverse reaction and usage of anal-gesic drugs.Conclusion Dexmedetomidine 0.4 μg · kg -1 injected intravenously can reduce the doses of drugs for anesthesia maintenance in patients undergoing combined hysteroscopy and laparoscopy , without a prolongation of extubation time , but can release postoperative pain , decrease the incidence of nausea , vomiting and shivering , and will save postoperative analgesics.
语种中文
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文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/72172
Collection北京大学第三临床医学院_麻醉科
作者单位1.北京大学 第三医院 麻醉科,北京,100191
2.北京大学 第三医院 生殖医学中心,北京,100191
Recommended Citation
GB/T 7714
俞晨,贾东林,张小青,等. 右美托咪定对宫腹腔镜手术患者镇痛疗效与安全性的研究[J]. 中国临床药理学杂志,2015(2):89-92.
APA 俞晨.,贾东林.,张小青.,孔丽娟.,李跃新.,...&王军.(2015).右美托咪定对宫腹腔镜手术患者镇痛疗效与安全性的研究.中国临床药理学杂志(2),89-92.
MLA 俞晨,et al."右美托咪定对宫腹腔镜手术患者镇痛疗效与安全性的研究".中国临床药理学杂志 .2(2015):89-92.
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