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其他题名Effects of different doses of gabapentin on streptozotocin-induced diabetic neuropathic pain
刘慧丽; 马璐璐; 龚亚红; 许力; 黄宇光; 罗爱伦
关键词环己酸类 糖尿病 神经痛 镇痛 Cyclohexanecarboxylic acids Diabetes mellitus Neuralgia Analgesia
收录类别中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型Journal Article
摘要目的 探讨不同剂量加巴喷丁对糖尿病神经病理性痛大鼠的镇痛效应.方法 健康雄性SD大鼠,周龄6周,体重180~200 g,腹腔注射链脲霉素60mg/kg制备糖尿病模型,取模型制备成功的大鼠24只,随机分为4组(n=6):对照组(C组)腹腔注射生理盐水0.6 ml;不同剂量加巴喷丁组(G_(1~3)组)分别腹腔注射加巴喷丁30、60或120 mg/kg,每日2次,每次注射量0.6 ml,连续给药21 d.于加巴喷丁给药前(T_0)、第1次给药后30 min(T_1)、60min(T_2)、120 min(T_3)、180 min(T_4)、240 min(T_5)及给药7 d(T_6)、14 d(T_7)、21 d(T_8)时测定大鼠机械痛阈.结果 各组大鼠机械痛阈基础值比较差异无统计学意义(P>0.05).与C组和G_1组比较,G_2组和G_3组机械痛阈升高(P<0.05);与G_2组比较,G_3组机械痛阈升高(P<0.05).与T_0时比较,G_2组T_(2~8)时机械痛阈升高,G_3组T_(1~8)时机械痛阈升高,两组均于T_2时达峰值(P<0.05).与T_2时比较,G_2组和G_3组T_(1,3~8)时机械痛阈降低(P<0.05).结论 加巴喷丁60和120 mg/kg对糖尿病神经病理性痛大鼠可产生镇痛效应,而长期应用可产生药物耐受现象. Objective To investigate the effects of different doses of gabapentin on streptozotocin (STZ)-induced diabetic neuropathic pain in rats.Methods Male SD rats aged 6 weeks weighing 180-200 g were used in this study. Diabetes ntellitus ( DM) was induced by intraperitoneal STZ 60 mg/kg and confirmed one week later by blood glucose =16.7 mmol/L before breakfast. The DM rats were randomly divided into 4 groups ( n = 6 each) : gabapentin groups received intraperitoneal gabapentin 30, 60 and 120 mg/kg twice a day (at 9:00 am and 3:00 pm) for 3 weeks respectively and control group received intraperitoneal normal saline 0.6 ml instead of gabapentin. The paw withdrawal threshold to von Frey filament stimulation was measured before and at 30, 60, 120, 180, 240 min after first gabapentin injection and once a week for 3 weeks. Results After gabapentin 60 and 120 mg/kg, the paw withdrawal threshold to mechanical stimuli was significantly increased and lasted for about 4 h. The analgesic effect peaked at 60 min after IP gabapentin injection. Normal saline and gabapentin 30 mg/kg had no significant analgesic effect. The degree of analgesia was significantly decreased at day 14 and 21 of treatment with gabapentin 60 and 120 mg/kg as compared with that at 60 min after gabapentin injection. Conclusion The hyperalgesia and allodynia in rats with diabetes mellitus can be effectively reversed by gabapentin 60 and 120 mg/kg,while long-term use of gabapentin can induce drug tolerance.
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GB/T 7714
刘慧丽,马璐璐,龚亚红,等. 不同剂量加巴喷丁对糖尿病神经病理性痛大鼠的镇痛效应[J]. 中华麻醉学杂志,2010,30(1):53-55.
APA 刘慧丽,马璐璐,龚亚红,许力,黄宇光,&罗爱伦.(2010).不同剂量加巴喷丁对糖尿病神经病理性痛大鼠的镇痛效应.中华麻醉学杂志,30(1),53-55.
MLA 刘慧丽,et al."不同剂量加巴喷丁对糖尿病神经病理性痛大鼠的镇痛效应".中华麻醉学杂志 30.1(2010):53-55.
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