IR@PKUHSC  > 北京大学第三临床医学院  > 麻醉科
学科主题麻醉学
右美托咪定对术中丙泊酚靶控输注效应室浓度及血流动力学的影响
其他题名Impact of dexmedetomidine on effect-site concentration of propofol with target controlled infusion and hemodynamics during operation
韩永正; 刘慧丽; 吴长毅; 郭向阳
关键词右美托咪定 丙泊酚 靶控输注 Dexmedetomidine Propofol Target controlled infusion
刊名国际麻醉学与复苏杂志
2014
DOI10.3760/cma.j.issn.1673-4378.2014.06.007
35期:6页:506-509
收录类别中国科技核心期刊
文章类型Journal Article
摘要目的 观察不同剂量的右美托咪定(dexmedetomidine,Dex)对术中丙泊酚靶控输注(target controlled infusion,TCI)效应室浓度(effect-ite concentration,Ce)及血流动力学的影响. 方法 采用前瞻性、随机、双盲、安慰剂平行对照的研究方法,选择60例在全凭静脉麻醉下择期行腹腔镜单纯胆囊切除术的患者,美国麻醉医师协会(ASA)分级Ⅰ~Ⅱ级,采用随机数字表法分为3组,每组20例.Dex 0.4 μg/kg(Dex1组)、Dex 0.5 μg/kg(Dex2组)和等容量生理盐水(NS组)在诱导开始时泵注,泵注时间为10 min.同时所有患者均采用相同的麻醉诱导及维持方案.分别于麻醉诱导前(T0)、切皮前(T1)、气腹后1(T2)、5(T3)、l0(T4)、20 min(T5)、放气腹后5 min(T6)记录收缩压(systolic blood pressure,SBP)、心率(heart rate,HR)、丙泊酚Ce.手术结束时记录丙泊酚所用总量. 结果 与NS组比较,Dex2组的SBP在T1时显著升高(P<0.01);与T0点比较,NS组的SBP在T1、T6点显著降低,Dexl、Dex2组在T1、T5、T6点均有显著降低;NS组丙泊酚使用量[(716±209) mg]显著高于Dex1组和Dex2组[(587±184) mg和(489±158) mg(P<0.05和P<0.0l)].Dex2组各时间点丙泊酚Ce均显著低于NS组(P<0.01),Dexl组在T2~T6时间点丙泊酚Ce显著低于NS组(T6时间点P<0.05,其余时间点P<0.01);使用0.4 μg/kg和0.5 μg/kg的Dex约节省丙泊酚18%和32%的用量. 结论 腹腔镜胆囊切除术中单次应用Dex可以维持围术期血流动力学平稳,显著降低术中丙泊酚效应室浓度,减少丙泊酚用量. Objective To evaluate effects of different doses of dexmedetomidine(Dex) on effect-site concentration (Ce) of propofol with target controlled infusion (TCI) and hemodynamics during operation.Methods A prospective,randomized,doubleblind and placebo controlled clinical protocol was used in this study.According to random number table,sixty patients (ASA Ⅰ-Ⅱ) undergoing laparoscopic cholecystectomy in total intravenous anesthesia were randomly allocated to three groups with 20 patients in each group.When the induction of anesthesia started,Dex 0.4 μg/kg (group Dexl),0.5 μg/kg (group Dex2) or the same volume of normal saline (group NS) was infused intravenously within 10 min.Meanwhile,all patients received the same method of induction and the maintenance of anesthesia.In three groups,the systolic blood pressure (SBP),heart rate (HR),and Ce of propofol were recorded before induction of anesthesia (T0),before skin incision (T1),1 min after pneumoperitoneum (T2),5 min after pneumoperitoneum (T3),10 min after pneumoperitoneum (T4),20 min after pneumoperitoneum (T 5),lifting of pneumoperitoneum after 5 min (T6).At the end of operation,the total dose of propofol was recorded.Results The SBP at T1 in group Dex2 was significantly higher than group NS (P<0.01).Compared with baseline,the SBP in group NS was significantly lower at T1 and T6.The SBP in group Dex1 and Dex2 were significantly lower at T1,T5,T6.More propofol consumed in group NS [(716±209) mg] than that in group Dex1 and in group Dex2[(587±184) mg and(489±158) mg(P<0.05)].In each time point,the propofol Ce in group Dex2 was significantly lower than group NS (P<0.01).From T2 to T6,the propofol Ce in group Dex1 was significantly lower than group NS (T6 time point P<0.05,other time points P<0.01).The dosage of propofol decreased by 18% and 32% respectively when combined with Dex 0.4 μg/kg and 0.5 μg/kg.Conclusions Infusion of Dex in laparoscopic cholecystectomy can stabilize the hemodynamics while decreasing the propofol Ce and reducing the consumption of of propofol.
语种中文
原文出处查看原文
Citation statistics
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/72211
Collection北京大学第三临床医学院_麻醉科
作者单位北京大学第三医院麻醉科,100191
Recommended Citation
GB/T 7714
韩永正,刘慧丽,吴长毅,等. 右美托咪定对术中丙泊酚靶控输注效应室浓度及血流动力学的影响[J]. 国际麻醉学与复苏杂志,2014,35(6):506-509.
APA 韩永正,刘慧丽,吴长毅,&郭向阳.(2014).右美托咪定对术中丙泊酚靶控输注效应室浓度及血流动力学的影响.国际麻醉学与复苏杂志,35(6),506-509.
MLA 韩永正,et al."右美托咪定对术中丙泊酚靶控输注效应室浓度及血流动力学的影响".国际麻醉学与复苏杂志 35.6(2014):506-509.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[韩永正]'s Articles
[刘慧丽]'s Articles
[吴长毅]'s Articles
百度学术
百度学术Similar articles in
[韩永正]'s Articles
[刘慧丽]'s Articles
[吴长毅]'s Articles
必应学术
必应学术Similar articles in
[韩永正]'s Articles
[刘慧丽]'s Articles
[吴长毅]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.