IR@PKUHSC  > 北京大学第三临床医学院  > 泌尿外科
其他题名Clinical analysis of permanent 125I prostate brachytherapy monotherapy for early prostate cancer ( report of 18 cases)
张治草; 黄毅; 马潞林; 张帆
关键词前列腺肿瘤 125I近距离放射疗法 Prostatic neoplasms Carcinoma 125I brachytherapy
收录类别中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型Journal Article
摘要目的 探讨单纯125I放射性粒子植入治疗早期前列腺癌的临床疗效. 方法 2007年1月至2011年7月前列腺癌患者18例,年龄60 ~ 81岁,平均74岁.术前PSA 0.38 ~ 8.73 μg/L,平均5.09 μg/L.均经前列腺穿刺病理诊断为前列腺癌,Gleason评分5~6分,临床分期T1c~T2a.采用直肠B超引导下经会阴植入125I粒子治疗. 结果 本组手术顺利,手术时间37~52 min,平均植入粒子54粒,术后住院时间3~4d.随访时间3~57个月,平均15个月,1例失访.随访17例血PSA无进展生存率为100% (17/17),7例随访超过18个月,血PSA水平长期低于0.20 μg/L,其中3例波动于0 ~0.08 μg/L,3例波动于0.02 ~0.12 μg/L,1例波动于0.12 ~ 0.20 μg/L.17例均未出现严重并发症. 结论 单纯125I放射性粒子植入治疗早期前列腺癌安全、有效. Objective To evaluate the clinical efficacy of permanent 125I prostate brachytherapy monotherapy in patients with early prostate cancer. Methods A total of 18 patients with prostate cancer was diagnosed by prostate biopsy,with Gleason score 5 - 6,average PSA 5.09 ng/ml (range,0.38 -8.73 ),and clinical stage T1c - T2a.All patients underwent 3-dimensional conformal brachytherapy with transperineal ultrasound-guide 125I seeds prostate implantation. Results None of the patients had any adverse events during the operation processes.The operation time was from 37 to 52 minutes and postoperative hospitalization time was from 3 to 4 days.The mean number of implanted 125I seeds was 54.All patients were followed up for 3 to 57 months with a mean of 15 months,while one patient was lost during followingup.The survival rate of PSA progression free was 100% (17/17).The PSA was under 0.2 ng/ml for a long time in the 7 cases who had been followed-up for more than 18 months.The PSA did not show any rising trend in all 17 cases.No severe complications occurred in all cases. Conclusions Brachytherapy monotherapy with 125I seeds implantation is safe and effective for patients with early prostate cancer.
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张治草,黄毅,马潞林,等. 单纯125I放射性粒子植入治疗早期前列腺癌的临床分析[J]. 中华泌尿外科杂志,2012,33(1):55-57.
APA 张治草,黄毅,马潞林,&张帆.(2012).单纯125I放射性粒子植入治疗早期前列腺癌的临床分析.中华泌尿外科杂志,33(1),55-57.
MLA 张治草,et al."单纯125I放射性粒子植入治疗早期前列腺癌的临床分析".中华泌尿外科杂志 33.1(2012):55-57.
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