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学科主题: 泌尿外科学
题名:
弱精子症大鼠模型的建立及左旋肉碱对其改善作用的相关研究
其他题名: Study on establishment of rat model with asthenospermic and melioration of asthenospermic treated by L-carnitine
作者: 柳建明; 姜辉; 洪锴; 白泉; 赵连明; 马潞林
关键词: 弱精子症 ; 肉碱 ; 奥硝唑 ; 附睾 ; asthenospermia ; L-carnitine ; ornidazole ; epididymis
刊名: 中国男科学杂志
发表日期: 2010
DOI: 10.3969/j.issn.1008-0848.2010.03.007
卷: 24, 期:3, 页:29-32
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的 研究弱精子症大鼠模型的建立及左旋肉碱(L-肉碱)与精子质量的关系.方法 24只雄性SD大鼠随机均分成3组,分别连续灌胃20d,A组(对照组):0.5%羟甲基纤维素钠(溶剂);B组:400mg/kg奥硝唑悬液:C组:400mg/kg奥硝唑悬液+100mg/kg左旋肉碱.末次给药24h后,麻醉处死所有大鼠,分别检测各组精子密度、活力、形态正常率以及附睾总L-肉碱和游离L-肉碱浓度.结果 A组、B组及C组的精子密度差异无统计学意义(P>0.05);A组、C组精子活力、精子形态正常率及附睾总L-肉碱、游离L-肉碱浓度均明显高于B组(P<0.05),A组与C组精子活力、精子形态正常率及附睾总L-肉碱、游离L-肉碱浓度比较,差异均无统计学意义.精子活力与附睾总L-肉碱、游离L-广肉碱浓度呈正相关(r=0.645,P<0.05:r=0.676,P<0.05),精子形态与附睾总L-肉碱、游离L-肉碱浓度呈正相关(r=0.557,P<0.05;r=0.583,P<0.05),均相关性其具有统计学意义.结论 奥硝唑可以降低大鼠精子活力、精子形态正常率,以及附睾L-肉碱水平,附睾L-肉碱浓度与精子活力、精子形态正常率呈正相关,L-肉碱对精子质量有改善作用. Objective To study the establishment of rat model with asthenospermia and the relationship between L-carnitine and sperm quality.Methods Twenty-four male SD rats were randomly divided into three groups (8 rats in each group).Rats in group A, group B and group C were treated consecutively by 0.5% carboxymethylcellulose solution, ,400 mg/kg ornidazole (ORN) and 400 mg/kg+ LC100 mg/kg via gastric garage for 20 days respectively.After treatment, the rats were killed, and then Sperm density, motility, the normal morphology rate of sperm and the concentration of L-carnitine in the epididymis were measured.Results No obvious changes in sperm density were found among group A, group B and groupC (P>0.05), but a significant decrease in sperm motility and morphology, as well as the concentration of L-carnitine in group B (P<0.05).There was a positive correlation between epididymal sperm motility/sperm morphology and the total L-carnitine/free (r= 0.645, P<0.05;r=0.676, P<0.05;r = 0.557, P <0.05;r=0.583, P <0.05).Conclusion Ornidazole could decrease sperm motility, sperm morphology and the epididymal L-carnitine level of rats.L-carnitine concentration of epididymis was positively correlated with sperm motility, sperm morphology.L-carnitine can improve sperm quality of rats.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/72444
Appears in Collections:北京大学第三临床医学院_泌尿外科_期刊论文

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作者单位: 北京大学第三医院泌尿男科,北京,100191

Recommended Citation:
柳建明,姜辉,洪锴,等. 弱精子症大鼠模型的建立及左旋肉碱对其改善作用的相关研究[J]. 中国男科学杂志,2010,24(3):29-32.
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