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学科主题: 内分泌
题名:
胰岛素受体底物-4基因多态性与2型糖尿病的相关性研究
其他题名: Association study of insulin receptor substrate-4 gene polymorphism with type 2 diabetes
作者: 王海宁; 洪天配; 徐希平
关键词: 2型糖尿病 ; 胰岛素 ; 基因 ; 多态现象 ; Polymorphism
刊名: 中国糖尿病杂志
发表日期: 2003
DOI: 10.3321/j.issn:1006-6187.2003.03.012
卷: 11, 期:3, 页:188-191
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的研究北京地区汉族人群胰岛素受体底物-4(IRS-4)基因密码子879 c/g多态性与2型糖尿病的相关性. 方法采用配偶对作病例-对照研究.用聚合酶链反应(PCR)-限制性内切酶片段长度多态性(RFLP)的方法检测IRS-4基因密码子879 c/g多态性. 结果 (1) 男性与女性间IRS-4基因密码子879 c/g多态性分布特点不同,男性无杂合子.g等位基因频率为男性61.8%,女性63.9%.(2)此多态性位点的基因型频率和等位基因频率在2型糖尿病组和对照组间差异无显著意义.(3)在男性对照组中,可见gg基因型组胰岛β细胞功能指数低于cc基因型组. 结论北京地区汉族人群中IRS-4基因密码子879 c/g多态性与2型糖尿病无明显相关性. Objective To study the association of insulin receptor substrate-4 (IRS-4) gene codon 879 c/g polymorphism with type 2 diabetes and its intermediate phenotypes in Chinese population in Beijing. Methods The IRS-4 gene codon 879 c/g polymorphism was detected by polymerase chain reaction and appropriate restriction enzyme (PCR-RFLP) in 110 type 2 diabetic cases and 80 normal controls. Results (1) There was different genotype distribution of IRS-4 codon 879 c/g polymorphism between the male and female groups. No heterozygote was found in male. The frequence of allele g was 61.8% in male and 63.9% in female respectively. (2) The genotype frequency and allelic frequency of the polymorphism were not significantly different between diabetics and control groups. (3) The islet β cell function index was lower in the individuals carrying the gg genotype than those carrying the cc genotype in male control group. Conclusions The gg geneotype of human IRS-4 codon 879 c/g polymorphism alone has no association with type 2 diabetes in northern Chinese population.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/72763
Appears in Collections:北京大学第三临床医学院_内分泌科_期刊论文

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作者单位: 1.100083,北京大学第三医院内分泌科
2.100083,北京大学生态遗传与生殖卫生研究中心

Recommended Citation:
王海宁,洪天配,徐希平. 胰岛素受体底物-4基因多态性与2型糖尿病的相关性研究[J]. 中国糖尿病杂志,2003,11(3):188-191.
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