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学科主题: 内分泌
题名:
胰岛素受体底物-2基因多态性与2型糖尿病的相关性研究
其他题名: Association study of insulin receptor substrate-2 gene polymorphism with type 2 diabetes
作者: 洪天配; 王海宁; 徐希平
关键词: 2型糖尿病 ; 胰岛素受体底物-2 ; 单核苷酸多态性 ; Single nucleotide polymorphism
刊名: 中国糖尿病杂志
发表日期: 2002
DOI: 10.3321/j.issn:1006-6187.2002.03.010
卷: 10, 期:3, 页:163-166
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的研究北京地区汉族人群中胰岛素受体底物-2(IRS-2)基因密码子1057 g/a多态性与2型糖尿病及其中间表型的相关性. 方法选取北京地区的中国汉族患者110例,对照组80例.用聚合酶链反应-限制性内切酶片段长度多态性(PCR-RFLP)的方法检测IRS-2基因密码子1057g/a多态性. 结果 (1) IRS-2基因密码子1057g/a多态性的a等位基因频率在糖尿病组和对照组中分别为26.4%和36.3%.(2) 糖尿病组aa基因型频率明显低于对照组,分别为5.5% 和18.7% (P=0.016).Logistic相关分析表明:aa基因型为2型糖尿病的保护性因素,OR值为0.28 (95% CI=0.09~0.91,P=0.03).(3) 不同基因型组间血压、血脂、胰岛素抵抗指数及胰岛β细胞功能指数等均差异无显著性. 结论中国北方地区汉族人群中IRS-2基因密码子1057 g/a多态性的aa基因型在2型糖尿病中明显减少,但2型糖尿病各种中间表型特征在不同基因型间均无明显差异.上述结果有待于进一步扩大样本量来加以确认. Objective To study the association of insulin receptor substrate 2 (IRS 2) gene codon 1057 g/a polymorphism with type 2 diabetes and its intermediate phenotypes in Chinese Han population in Beijing. Methods The IRS 2 gene codon 1057 g/a polymorphism was detected by polymerase chain reaction and appropriate restriction enzyme (PCR RFLP) in 110 type 2 diabetic cases and 80 normal controls. Results (1) The frequency of allele a was 26.4% in case group and 36.3% in control group. (2) The aa genotype frequency of the polymorphism was significantly lower in the case group than in the control group, 5.5% and 18.7% respectively ( P= 0.016). Logistic regression analysis showed the aa genotype might be a preventive factor of type 2 diabetes, with OR=0.28 (95% CI=0.09 0.91, P= 0.03). (3) No matter in the case group or in the control group, there was no significant difference in blood pressure, blood lipid profile, islet β cell function index or insulin resistant index, etc. among three groups with different genotypes. Conclusion The aa genotype of IRS 2 gene codon 1057 g/a polymorphism has a significantly lower distribution in type 2 diabetes group than that in the control group in northern chinese population, but is not associated with any intermediate phenotypes of type 2 diabetes. The results have to be confirmed by the future study in which the volume of research sample should be enlarged.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/72768
Appears in Collections:北京大学第三临床医学院_内分泌科_期刊论文

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作者单位: 1.100083,北京大学第三医院内分泌科
2.北京大学生态遗传与生殖卫生研究中心

Recommended Citation:
洪天配,王海宁,徐希平. 胰岛素受体底物-2基因多态性与2型糖尿病的相关性研究[J]. 中国糖尿病杂志,2002,10(3):163-166.
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