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学科主题: 内分泌
题名:
2型糖尿病患者氟-18标记脱氧葡萄糖心肌代谢显像图像质量与相关代谢因素的分析
其他题名: Study on the relationship between the metabolic factors and the quality of 18F-fluorode oxyglucose myocardial metabolic imaging in patients with type 2 diabetes
作者: 王海宁; 方纬; 刘辰; 苏保满; 高洪伟; 洪天配; 何作祥
关键词: 氟脱氧葡萄糖F18 ; 放射性核素心室显像术,糖尿病,2型 ; Fluorodeoxyglucose F18 ; Radionuelide ventrieulography ; Diabetes mellitus,type 2
刊名: 中华老年医学杂志
发表日期: 2009
DOI: 10.3760/cma.j.issn.0254-9026.2009.01.003
卷: 28, 期:1, 页:11-14
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的 探讨2型糖尿病患者氟-18标记脱氧葡萄糖(18FDG)心肌代谢显像图像质量与相关代谢因素的关系. 方法 70例年龄≥60岁的2型糖尿病并存冠心病患者,行18F-FDG心肌代谢显像.并于显像当日测定血糖、糖化血红蛋白(HbA1c)、胰岛素和C肽、总胆固醇、三酰甘油、低密度脂蛋白胆同醇和高密度脂蛋白胆固醇等指标,计算HOMA胰岛素抵抗指数和HOMA胰岛β细胞功能指数.图像质量评定采用评分法. 结果与图像质量不佳组(36例)比较,图像质量良好组(34例)的患者年龄较小,分别为(62.2±8.5)岁和(67.6±8.3)岁(P<0.01);体质指数(body massindex,BMI)较小,分别为(24.7±2.6)kg/m2和(26.1±2.5)kg/m2(P<0.05);空腹胰岛素和C肽水平明显降低,分别为8.3(5.1~12.4)mlu/L和12.2(6.1~17.9)mlu/L(P<0.05)、0.6(0.5~0.9)nmol/L和0.9(0.6~1.2)nm01/L(P<0.05).图像质量好组HOMA胰岛素抵抗指数低于图像质量不佳组,分别为2.7(1.6~4.0)和4.1(1.7~6.5)(P<0.05).Logistic回归分析显示,肥胖是图像质量不佳的独立因素,校正其它代谢指标后的OR值为3.73(95%CJ为1.12~12.45,P<0.05).年龄也是影响图像质量的危险因素,大于65岁的OR值为4.64(95%CI,1.46~14.7,P<0.05),校正BMI等因素后OR值为3.75(95%CI,0.96~14.6,P>0.05) 结论影响2型糖尿病患者18F-FDG心肌代谢显像图像质量的主要代谢因素是胰岛素抵抗,此外年龄、肥胖也是影响图像质量的重要因素. Objective To evaluate the effects of metabolic factors on the quality of 18F-fluorode oxyglucose (18F-FDG) myocardial metabolic imaging in coronary artery disease (CAD) patients with type 2 diabetes mellitus (T2DM). Methods Seventy CAD patients aged 60 years or over with T2DM were studied with myocardial 18 F-FDG dual isotope simultaneous acquisition (DISA) single photon emission computed tomography (SPECT). Fasting plasma glucose, total triglyceride (TG),total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-eholesterol(LDL-C), insulin, C peptide and glyeosylated hemoglobia (HbAlc) were detected. Insulin resistance and islet β cell function were calculated by using the Homeostasis Model Assessment (HOMA) equation. Results Compared with the bad image quality group (36 cases), patients in the excellent image quality group (34 cases) were younger [with average age of (62.2±8.5) years vs. (67.6±8.3) years, P<0.01] and slimmer [with BMI of (24.7±2.6)kg/m2 vs. (26.1±2.5)kg/m2, P<0.05]. The levels of fasting insulin and C peptide were lower in the excellent image quality group than those in the bad image quality group [with fasting insulin level of 8.3 (5.1~12.4) mIu/L vs. 12.7,(6.1~17.9)mIu/L and C-peptide level of 0.6(0.5~0.9)nmol/L vs. 0.9(0.6~1.2)nmol/L, respectively,both P<0.05]. The HOMA insulin resistant index was reduced in the excellent image group [2.7(1.6~4.0) vs. 4.1(1.7~6.5), P<0.05]. Logistic regression analysis showed that obesity and age≥65 years were independent risk factors for image quality, with OR value of 3.73 (95% CI: 1.12~12.45,P=0.022)and 3.75 (95%CI:0.96~14.6,P=0.058)after adjustment of other metabolic factors. Conclusions Insulin resistance is the main factor that influences the quality of 18F-FDG myocardial metabolic imaging in patients with T2DM. In addition, age≥65 years and obesity are also risk factors for image quality.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/72772
Appears in Collections:北京大学第三临床医学院_内分泌科_期刊论文

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作者单位: 1.100083,北京大学第三医院内分泌科
2.中国医学科学院阜外心血管病医院核医学科

Recommended Citation:
王海宁,方纬,刘辰,等. 2型糖尿病患者氟-18标记脱氧葡萄糖心肌代谢显像图像质量与相关代谢因素的分析[J]. 中华老年医学杂志,2009,28(1):11-14.
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