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学科主题: 内分泌
题名:
胰升糖素样肽1:非酒精性脂肪性肝病治疗的新靶点?
其他题名: Glucagon-like peptide-1 : New target for treating non-alcoholic fatty liver disease?
作者: 刘烨; 洪天配; 魏蕊; 杨进
关键词: 非酒精性脂肪性肝病 ; 胰升糖素样肽1 ; 二肽基肽酶-4 ; Non-alcoholic fatty liver disease ; Glucagon-like peptide-1 ; Dipeptidyl peptidase-4
刊名: 中华内分泌代谢杂志
发表日期: 2015
DOI: 10.3760/cma.j.issn.1000-6699.2015.05.002
卷: 31, 期:5, 页:386-389
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 非酒精性脂肪性肝病(NAFLD)患者存在胰升糖素样肽1(GLP-1)信号受损.天然GLP-1或GLP-1类药物可通过GLP-1受体对肝细胞发挥直接作用,包括改善胰岛素抵抗、抑制氧化应激、调控脂代谢相关基因表达等.临床研究显示GLP-1类药物能够改善NAFLD患者的代谢指标和肝脏病变. Recent studies have demonstrated an association of glucagon-like peptide-1 (GLP-1) signaling defect with non-alcoholic fatty liver disease (NAFLD).Native GLP-1 and GLP-1-based agents may directly act on hepatocytes through activation of GLP-1 receptors in hepatocytes,resulting in the regulation of gene expression associated with insulin resistance and lipid metabolism,and the suppression of oxidative stress in liver cells.Moreover,GLP-1-based agents have been reported to be effective in improving hepatic endpoints in patients with NAFLD.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/72793
Appears in Collections:北京大学第三临床医学院_内分泌科_期刊论文

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作者单位: 100191,北京大学第三医院内分泌科

Recommended Citation:
刘烨,洪天配,魏蕊,等. 胰升糖素样肽1:非酒精性脂肪性肝病治疗的新靶点?[J]. 中华内分泌代谢杂志,2015,31(5):386-389.
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