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学科主题: 内分泌
题名:
GYS1和β3-AR基因与2型糖尿病餐后高血糖和血尿酸的关系
其他题名: Association of GYS1 and β3-AR gene with postprandial hyperglycemia and serum uric acid in type 2 diabetes mellitus
作者: 王国英; 李琼芳; 牛天华; 陈常中; 徐希平
关键词: 肌肉糖元合酶基因 ; β3肾上腺素能受体基因 ; 2型糖尿病 ; 餐后血糖 ; 血尿酸 ; muscle glycogen synthase gene ; β3-adrenergic-receptor gene ; type 2 diabetes mellitus ; postprandial glucose ; serum uric acid
刊名: 中华医学杂志(英文版)
发表日期: 2002
DOI: 10.3760/j.issn:0366-6999.2002.09.006
卷: 115, 期:9, 页:1308-1311
文章类型: Journal Article
摘要: 目的探讨中国人群中肌肉糖元合酶(GYS1)基因多态性和β3肾上腺素能受体(β3-AR)基因Trp64Arg变异与2型糖尿病及其中间表型的相关性. 方法采用聚合酶链反应-寡核苷酸连接测定及限制性片断长度多态性方法,对北京地区102对病例-对照配偶对进行GYS1基因Met416Val和 XbaⅠ多态性以及β3-AR基因Trp64Arg多态性的基因型检测. 结果糖尿病组中携带Val416等位基因组餐后2小时血糖值显著高于无变异组(P=0.032);Met416Val 多态性与2型糖尿病不相关(调整 OR=1.67; 95%CI: 0.73-3.81, P=0.223);在糖尿病组Trp64Arg突变携带者与非携带者相比血尿酸显著升高P=0.034;Arg64联合高BMI时可使2型糖尿病发病危险增加4倍(调整OR=4.00; 95%CI: 1.53-10.45, P=0.005).结论在中国人群中Met416Val变异与2型糖尿病的餐后2小时血糖相关,可以部分解释某些2型糖尿病患者的餐后高血糖;糖尿病患者携带Arg64等位基因可以预示具有较高的血尿酸水平. Objective To determine the relationships of Met416Val and XbaI polymorphism of muscle glycogen synthase (GYS1) gene and Trg64Arg variant of the β3-adrenergic-receptor (β3-AR) gene with type 2 diabetes mellitus (DM) and its intermediate phenotypes in the Chinese population. Methods Polymerase chain reaction-oligonucleotide ligation assay and restriction fragment length polymorphism assay were used to evaluate the GYS1 and β3-AR gene polymorphisms in 102 pairs of case-control Chinese spouses. Results Subjects with Met416Val variant had a significantly higher 2-hour post-glucose level than subjects without this variant had in diabetic group (P=0.032). The Met416Val polymorphism of GYS1 gene was not significantly associated with the risk of type 2 DM (adjusted OR=1.67; 95% CI: 0.73-3.81, P=0.223). Subjects with Trp64Arg variant had a significantly higher serum uric acid level than subjects without this variant had in diabetic group (P=0.034). The combination of BMI and Arg64 allele carrier of the β3-AR gene increased the diabetic risk over four-fold (adjusted OR=4.00; 95%CI: 1.53-10.45, P=0.005). Conclusions In the Chinese population, Met416Val polymorphism is identified in a subgroup of diabetic subjects with high 2-hour post-glucose. It will explain why some diabetic patients appear to be genetically predisposed to developing high postpradial glucose level. The presence of the Arg64 allele in the β3-AR gene may predispose patients to higher serum uric acid level.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/72891
Appears in Collections:北京大学第三临床医学院_内分泌科_期刊论文

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作者单位: 1.北京大学第三医院内分泌科,北京,100083
2.The Program of Population Genetics, Harvard School of Public Health, Boston, MA 02115-6096, USA

Recommended Citation:
王国英,李琼芳,牛天华,等. GYS1和β3-AR基因与2型糖尿病餐后高血糖和血尿酸的关系[J]. 中华医学杂志(英文版),2002,115(9):1308-1311.
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