北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 内分泌科  > 期刊论文
学科主题: 内分泌
题名:
PPP1R3基因多态性与2型糖尿病相关性研究
其他题名: The association between PPP1R3 gene polymorphisms and type 2 diabetes mellitus
作者: 王国英; 李琼芳; 牛天华; 陈常中; 钱荣立
关键词: 2型糖尿病 ; 蛋白磷酸酶1糖原靶调节亚单位基因 ; 多态性 ; type 2 diabetes mellitus ; PPP1R3 gene ; polymorphism
刊名: 中华医学杂志(英文版)
发表日期: 2001
DOI: 10.3760/j.issn:0366-6999.2001.12.006
卷: 114, 期:12, 页:1258-1262
文章类型: Journal Article
摘要: 目的应用病例对照分析法对骨骼肌糖原相关蛋白磷酸酶1的糖原靶调节亚单位基因多态性与2型糖尿病相关性进行研究。方法应用寡核苷酸连接测定技术和直接电泳的方法,对该基因的Asp905Tyr和3'非翻译区ARE多态性位点基因型进行了测定。结果 BMI25携带Asp905等位基因组能增加2型糖尿病的危险(OR=3.66; 95% CI: 1.48-9.06);ARE多态性与2型糖尿病未见相关(OR=1.15; 95% CI: 0.62-2.14)。结论 Asp905协同肥胖增加2型糖尿病的危险。在中国人群中,该基因的Asp905Tyr和ARE多态性不是致糖尿病基因主要的变异。 Objective To detect the relationship between the polymorphism of the glycogen-targeting regulatory subunit of the skeletal muscle glycogen-associated protein phosphatase 1 (PPP1R3) gene and type 2 diabetes by case-control study. Methods We genotyped the PPP1R3 gene Asp905Tyr polymorphism and a common 3'-untranslated region AT (AU)-rich element (ARE) polymorphism in 101 type 2 diabetic patients and 101controls by oligonucleotide ligation assay (OLA) and polyacrylamide gel elecrophoresis, respectively. Results Subjects with Tyr/Tyr genotypes whose body mass index (BMI)<25 were used as the reference group. Those whose BMI25 with Asp905 had a 3.66-fold increase (95% CI: 1.48-9.06, P=0.005) in type 2 diabetes risk. No association was found between 3'UTR ARE polymorphism and type 2 diabetes mellitus (OR=1.15; 95% CI: 0.62-2.14, P=0.65). Conclusion A joint effect between the Asp905 and BMI increases the risk of type 2 diabetes, and Asp905Tyr and ARE polymorphism of PPP1R3 gene are not the major diabetogenic gene variants in Chinese population.
语种: 中文
原文出处: 查看原文
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/72892
Appears in Collections:北京大学第三临床医学院_内分泌科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.北京大学第三医院内分泌科,北京,100083
2.北京大学第一医院内分泌科,北京,100034

Recommended Citation:
王国英,李琼芳,牛天华,等. PPP1R3基因多态性与2型糖尿病相关性研究[J]. 中华医学杂志(英文版),2001,114(12):1258-1262.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[王国英]'s Articles
[李琼芳]'s Articles
[牛天华]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[王国英]‘s Articles
[李琼芳]‘s Articles
[牛天华]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace