IR@PKUHSC  > 北京大学第三临床医学院  > 皮肤科
学科主题皮肤病与性病学
曲安奈德益康唑乳膏长疗程间歇疗法治疗局限性慢性湿疹
其他题名Long-term intermittent treatment of localized chronic eczema with triamcinolone acetonide and econazole nitrate cream
路雪艳; 李邻峰; 王文慧; 曹源; 刘广仁
关键词湿疹 长疗程间歇疗法 外用激素 Eczema Long-term intermittent treatment Topical corticosteroids
刊名中华皮肤科杂志
2010
DOI10.3760/cma.j.issn.0412-4030.2010.06.006
43期:6页:390-392
收录类别中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型Journal Article
摘要目的 探讨外用糖皮质激素长疗程间歇疗法治疗局限性慢性湿疹的疗效、安全性及复发情况,以指导临床用药.方法 选取门诊局限性慢性湿疹患者,外用曲安奈德益康唑乳膏短程治疗.症状积分下降指数(SSRI)≥190%的患者进入长疗程,随机分两组,分别外用曲安奈德益康唑乳膏和润肤霜,间歇用药,共治疗8周.长疗程治疗4周、8周时及长疗程治疗停药12周时各随访1次.结果 长疗程治疗8周及停药12周时,曲安奈德益康唑组SCORAD评分均显著低于润肤霜组(t值分别为3.076和2.367,P值均<0.05).长疗程治疗4周、8周及停药12周时,曲安奈德益康唑组复发率均显著低于润肤霜组(x2值分别为4.426、7.683、8.199,P值均<0.05).治疗期间不良反应发生率3.1%,无严重不良事件.结论 外用糖皮质激素长疗程间歇治疗慢性湿疹,有防止症状加重、延缓湿疹复发的作用. Objective To investigate the efficacy and safety of long-term intermittent treatment with topical corticosteroids in localized chronic eczema.Methods A total of 129 patients with localized chronic eczema were treated with triamcinolone acetonide and econazole nitrate cream (Pevisone (R)).Those who achieved a clinical cure within 4-week treatment were recruited into the following long-term study and classifled into 2 groups to be intermittently treated with triamcinolone acetonide and econazole nitrate cream or a moisturizing cream for 8 weeks.The cream was applied topically twice a day for 2 days every week.Patients were followed up on week 4 and 8 after the beginning of treatment and on week 12 after the discontinuation of treatment.The severity of eczema in patients was rated according to SCORAD (SCORing atopic dermatitis) score.Results The SCORAD score was significantly lower in patients treated with triamcinolone acetonide and econazole nitrate cream than in those with moisturizing cream on week 8 in the treatment and week 12 after the discontinuation (t=3.076,2.367,both P<0.05).A statistical decrease was also observed in the recurrence rate of eczema in patients treated with triamcinolone acetonide and econazole nitrate cream compared with moisturizing cream.treated patients at the 3 follow-up time points (x2=4.426,7.683,8.199,all P<0.05).The incidence of adverse events was 3.1% during the treatment with triamcinolone acetonide and econazole nitrate cream.No severe adverse reactions were observed.Conclusion Long-term intermittent treatment with topical corticosteroids is effective for the prevention of exacerbation and postponement of recurrence,of eczema.
语种中文
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文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/72981
专题北京大学第三临床医学院_皮肤科
作者单位北京大学第三医院皮肤科,100191
推荐引用方式
GB/T 7714
路雪艳,李邻峰,王文慧,等. 曲安奈德益康唑乳膏长疗程间歇疗法治疗局限性慢性湿疹[J]. 中华皮肤科杂志,2010,43(6):390-392.
APA 路雪艳,李邻峰,王文慧,曹源,&刘广仁.(2010).曲安奈德益康唑乳膏长疗程间歇疗法治疗局限性慢性湿疹.中华皮肤科杂志,43(6),390-392.
MLA 路雪艳,et al."曲安奈德益康唑乳膏长疗程间歇疗法治疗局限性慢性湿疹".中华皮肤科杂志 43.6(2010):390-392.
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