北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 泌尿外科  > 期刊论文
学科主题: 泌尿外科学
题名:
前列腺癌和癌旁组织中雌激素受体α和β的表达及意义
其他题名: Expression and significance of estrogen receptor α and β in prostate cancer and peri-cancer tissue
作者: 马然; 卢剑; 陆敏; 刘余庆; 纪翔; 马潞林
关键词: 雌激素受体α ; 雌激素受体β ; 前列腺肿瘤 ; ; 前列腺增生 ; Estrogen receptor alpha ; Estrogen receptor beta ; Prostatic neoplasms ; Carcinoma ; Prostatic hyperplasia
刊名: 中华泌尿外科杂志
发表日期: 2011
DOI: 10.3760/cma.j.issn.1000-6702.2011.04.015
卷: 32, 期:4, 页:265-268
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的 通过测定前列腺癌中癌组织、癌旁组织和良性前列腺增生组织中雌激素受体(estrogen receptor,ER)α和β的表达水平,探讨ER在前列腺腺癌发生、发展中的变化和作用机制.方法 采用超高敏链酶亲合素-过氧化物酶法检测28例前列腺腺癌标本中癌和癌旁组织以及29例良性前列腺增生组织中ERα和ERβ的表达水平,对比其在各组之间表达的差异,分析ERα和ERβ的表达水平与前列腺癌患者的Gleason评分、临床分期、年龄和TPSA的关系.结果 前列腺癌组织中ERα主要在间质细胞表达.ERα在前列腺癌组织、癌旁组织和良性前列腺增生组织上皮细胞的表达阳性率分别为0%、14%、24%,间质细胞阳性率分别为57%、68%、31%,组间比较差异有统计学意义(P<0.05).前列腺癌上皮细胞和间质细胞均有ERβ的表达且差异无统计学意义(P>0.05).ERβ在前列腺癌组织、癌旁组织和良性前列腺增生组织上皮细胞的表达阳性率分别为39%、64%、29%;间质细胞阳性率分别为50%、75%、79%,组间比较差异有统计学意义(P<0.05).ERβ在不同Gleason评分前列腺癌组织中表达差异有统计学意义(P<0.05).结论 前列腺癌中ERα主要在间质细胞表达;ERβ在上皮细胞和间质细胞均有表达.ERα和ERβ的表达水平在前列腺癌组织、癌旁组织和良性前列腺增生组织均存在差异.ER口与前列腺癌变发生和恶性程度相关. Objective To investigate the expression of estrogen receptor (ER) α and β in human prostate cancer (PC), peri-cancer tissue and benign prostatic hyperplasia (BPH) tissue, and to discuss the role of estrogen receptor in prostate cancer. Methods The expression of ERα and ERβ in PC (n=28), peri-cancer tissue (n=28) and BPH (n=29) were detected by immunohistochemistry with En vision method. The ERα and ERβ expression were compared among different tissues by chisquare. The relationship between ER expression and related clinicopathologic features was statistically analyzed by spearman rank collection. Results ERα was localized dominantly in the stromal cell of PC. There were significant differences of the expression of ERα in PC, peri-cancer tissue and BPH tissue (epithelial cell 0%, 14%, 24%, P<0. 05; stromal cell 57%, 68%, 31%,P<0. 05). ERβ was localized in both epithelial and stromal cell of PC. There were significant differences of the expression of ERβ in PC, peri-cancer tissue and BPH tissue (epithelial cell 39%, 64%, 29%, P<0.01; stromal cell 50%, 75%, 79%, P<0.05). There was a significant difference of the expression of ERβ in different Gleason scores of PC tissue. Conclusions ERα is localized in the stromal cell of PC tissue.ERβ is localized in both epithelial and stromal cell of PC tissue. The ERβ might be related to the tumor differentiation of PC.
语种: 中文
原文出处: 查看原文
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/73818
Appears in Collections:北京大学第三临床医学院_泌尿外科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.北京大学第三医院泌尿外科,100191
2.北京大学基础医学院病理学系

Recommended Citation:
马然,卢剑,陆敏,等. 前列腺癌和癌旁组织中雌激素受体α和β的表达及意义[J]. 中华泌尿外科杂志,2011,32(4):265-268.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[马然]'s Articles
[卢剑]'s Articles
[陆敏]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[马然]‘s Articles
[卢剑]‘s Articles
[陆敏]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace