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学科主题: 内分泌
题名:
PPARγ2基因多态性与2型糖尿病相关性研究
其他题名: The association study between peroxisome proliferator-activated receptor γ2 gene polymorphism and type 2 diabetes mellitus
作者: 王国英; 李琼芳; 邓正照; 洪天配; 张路; 牛天华; 徐希平
关键词: 过氧化物酶增殖物活化受体γ2基因 ; 2型糖尿病 ; 多态性 ; Peroxisome proliferator activated receptorγ2 gene Type 2 diabetes mellitus Polymorphism
刊名: 中国糖尿病杂志
发表日期: 2002
DOI: 10.3321/j.issn:1006-6187.2002.02.003
卷: 10, 期:2, 页:74-76,73
收录类别: 中国科技核心期刊 ; 中文核心期刊 ; CSCD
文章类型: Journal Article
摘要: 目的旨在研究过氧化物酶增殖物活化受体γ2(PPARγ2)基因Pro12Ala多态性与2型糖尿病相关性.方法选取北京地区汉族101对病例-对照配偶对,应用聚合酶链反应-长度多态性方法进行基因型测定.结果对照组中携带Ala12等位基因组,血清载脂蛋白B明显低于Pro12Pfo基因型组(P=0.006);但Pro12Ala多态性与2型糖尿病不相关(OR=1.48,95%CI=0.52~4.18,P=0.461).结论在北京汉族人群中,PPARγ2基因Pro12Ala多态性与脂肪代谢异常有关,PPARγ2基因多态性可能不是2型糖尿病主要的致病因素. Objective To study the association of peroxisome proliferator activated receptorγ2 (PPARγ2) gene polymorphism with type 2 diabetes mellitus.Methods PPARγ2 gene Pro12Ala polymorphism was examined using polymerase chain reaction and restriction fragment length polymorphism (PCR RFLP) in 101 couples of type 2 diabetes mellitus normal control.Results In control group, heterozygosity carriers had lower serum apolipoprotein B (P=0 006).The Pro12Ala polymorphism in PPARγ2 gene is not associated with type 2 diabetes mellitus(OR=1.48,95%CI=0.52~4.18,P=0.461).Conclusion PPARγ2 gene Pro12Ala polymorphism is associated with abnormal lipid metabolism; PPARγ2 gene may not play a critical role in the development of type 2 diabetes mellitus in Han of Beijing Chinese.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/73831
Appears in Collections:北京大学第三临床医学院_内分泌科_期刊论文

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作者单位: 1.北京大学第三医院内分泌科,100083
2.美国哈佛大学公共卫生学院

Recommended Citation:
王国英,李琼芳,邓正照,等. PPARγ2基因多态性与2型糖尿病相关性研究[J]. 中国糖尿病杂志,2002,10(2):74-76,73.
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