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学科主题: 内分泌
题名:
核素分子影像技术在胰岛β细胞显像中的研究进展
其他题名: Advances in radionuclide molecular imaging of pancreatic β-cells
作者: 刘烨; 方纬; 洪天配; 朱朝晖; 王海宁
关键词: 胰岛 ; 放射性核素显像 ; 分子显像 ; 发展趋势 ; Islets of langerhans ; Radionuclide imaging ; Molecular Imaging ; Trends
刊名: 中华核医学与分子影像杂志
发表日期: 2013
DOI: 10.3760/cma.j.issn.2095-2848.2013.01.022
卷: 33, 期:1, 页:74-78
收录类别: 中国科技核心期刊 ; CSCD
文章类型: Journal Article
摘要: 1型和2型DM均存在不同程度的胰岛β细胞数量(BCM)减少,定量评估体内现存的BCM对阐明β细胞相关代谢疾病的发病机制、早期诊断、监测疾病进展具有重要作用.目前尚无有效的方法在体对BCM进行早期、精确的测量.很多学者用基于受体、抗体、FDG及报告基因的显像技术在胰岛β细胞显像方面进行了探索,笔者对核素胰岛β细胞显像的进展进行综述. In both type 1 and type 2 diabetes mellitus,β-cell mass (BCM) is lost.Various treatments are developed to restore or reconstruct BCM.The development of non-invasive methods to quantify BCM in vivo offers the potential for early detection of β-cell dysfunction prior to the clinical onset of diabetes.PET imaging with radioligands that directly target the pancreatic β-cells appears promising.The ability to determine the BCM has been investigated in several targets and their corresponding radiotracers,including radiolabeled receptor ligands,antibodies,metabolites and reporter genes.Therefore,we summarize the recent progress in radionuclide molecular imaging of pancreatic β-cells.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/74609
Appears in Collections:北京大学第三临床医学院_内分泌科_期刊论文

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作者单位: 1.100191,北京大学第三医院内分泌科
2.中国医学科学院、北京协和医学院阜外心血管病医院核医学科
3.中国医学科学院、北京协和医学院北京协和医院核医学科

Recommended Citation:
刘烨,方纬,洪天配,等. 核素分子影像技术在胰岛β细胞显像中的研究进展[J]. 中华核医学与分子影像杂志,2013,33(1):74-78.
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