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学科主题: 临床医学
题名:
帕金森病患者载脂蛋白E基因多态性与痴呆相关性的分析
其他题名: Analysis the polymorphism of apolipoprotein E gene in patients of parkinson disease with dementia
作者: 王芬; 李美琳; 杨志杰
关键词: 载脂蛋白E ; 基因 ; 帕金森病 ; 痴呆
刊名: 现代康复
发表日期: 2001
DOI: 10.3321/j.issn:1673-8225.2001.03.026
卷: 5, 期:3, 页:50-51
文章类型: Journal Article
摘要: 目的了解帕金森病痴呆(PDD)与载脂蛋白E(apoE)基因多态性的关系,探讨PDD的发病机制。方法应用PCR-RFLP技术检测11例PDD患者,40例帕金森病(PD)非痴呆患者和52例无关对照的apoE基因型。结果PDD组、PD非痴呆组和对照组在apoE等位基因频率及基因型分布上均无显著差异(P>0.05)。结论PDD的发病与apoE基因多态性无关,其发病的生物遗传学基础有别于Alzheimer病(AD)。 Objective To study the relationship between PDD and the polymorphism of apolipoprotein E(apoE) gene,to inquire the etiological basis of PDD.Methods 11 Patients with PDD 40 patients with PD without dementtia and 52 unrelated controls were collected to detect the genotype of apoE gene by PCR- RFLP. Results There was no difference in the apoE allele frequencies and genotype distribution in PDD group,PD without dementia group and control group(P >0.05). Conclusion There is no relationship between the polymorphism of apoEgene and the onset of PDD.The pathogenesis of PDD differs from that of AD.
语种: 中文
原文出处: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/75192
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 北京医科大学第三医院,

Recommended Citation:
王芬,李美琳,杨志杰. 帕金森病患者载脂蛋白E基因多态性与痴呆相关性的分析[J]. 现代康复,2001,5(3):50-51.
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