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Delivery Pathway Regulation of 3 ′,3 ′′-Bis-Peptide-siRNA Conjugate via Nanocarrier Architecture Engineering 期刊论文
MOLECULAR THERAPY-NUCLEIC ACIDS, 2018, 卷号: 10, 期号: 0, 页码: 75-90
作者:  Sun, Jing;  Qiu, Chong;  Diao, Yiping;  Wei, Wei;  Jin, Hongwei;  Zheng, Yi;  Wang, Jiancheng;  Zhang, Lihe;  Yang, Zhenjun
收藏  |  浏览/下载:3/0  |  提交时间:2018/05/17
Selective inhibition of TRPM2 channel by two novel synthesized ADPR analogues 期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2018, 卷号: 91, 期号: 2, 页码: 552-566
作者:  Luo, Xiao;  Li, Meng;  Zhan, Kaiyu;  Yang, Wei;  Zhang, Lihe;  Wang, KeWei;  Yu, Peilin;  Zhang, Liangren
收藏  |  浏览/下载:4/0  |  提交时间:2018/03/15
ADPR analogues  inhibitor  selectivity  TRP channels  TRPM2  
The Bioactivity of D-/L-Isonucleoside- and 2 ′-Deoxyinosine-Incorporated Aptamer AS1411s Including DNA Replication/MicroRNA Expression 期刊论文
MOLECULAR THERAPY-NUCLEIC ACIDS, 2017, 卷号: 9, 页码: 218-229
作者:  Fan, Xinmeng;  Sun, Lidan;  Li, Kunfeng;  Yang, Xiantao;  Cai, Baobin;  Zhang, Yanfen;  Zhu, Yuejie;  Ma, Yuan;  Guan, Zhu;  Wu, Yun;  Zhang, Lihe;  Yang, Zhenjun
收藏  |  浏览/下载:4/0  |  提交时间:2018/03/15
阳离子脂材混合中性胞嘧啶脂材转染3′,3′′-双肽siRNA缀合物研究(英文) 期刊论文
Journal of Chinese Pharmaceutical Sciences, 2017, 期号: 10, 页码: 719-726
作者:  杨梦依;  孙晶;  王超;  张艳芬;  张礼和;  杨振军
Adobe PDF(1008Kb)  |  收藏  |  浏览/下载:1/0  |  提交时间:2018/05/08
3′  3′′-双肽-siRNA缀合物  Gemini-like阳离子脂质  中性胞嘧啶脂材  黑色素瘤治疗  
Construction of an inducible stable cell line for efficient incorporation of unnatural amino acids in mammalian cells 期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 卷号: 489, 期号: 4, 页码: 490-496
作者:  Zhang, Ziwei;  Xu, Huan;  Si, Longlong;  Chen, Yi;  Zhang, Bo;  Wang, Yan;  Wu, Yiming;  Zhou, Xueying;  Zhang, Lihe;  Zhou, Demin
收藏  |  浏览/下载:1/0  |  提交时间:2017/11/02
Unnatural Amino Acid  Mammalian Cells  Incorporation Efficiency  Engineered Erf1  
Design, Synthesis and Biological Evaluation of Pentacyclic Triterpene Dimers as HCV Entry Inhibitors 期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2017, 卷号: 35, 期号: 8, 页码: 1322-1328
作者:  Meng, Lingkuan;  Wang, Qi;  Tang, Tao;  Xiao, Sulong;  Zhang, Lihe;  Zhou, Demin;  Yu, Fei
收藏  |  浏览/下载:4/0  |  提交时间:2017/11/02
Pentacyclic Triterpene  Echinocystic Acid  Dimer  Hcv Entry Inhibitor  
Alkylation of phosphorothioated thrombin binding aptamers improves the selectivity of inhibition of tumor cell proliferation upon anticoagulation 期刊论文
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2017, 卷号: 1861, 期号: 7, 页码: 1864-1869
作者:  Yang, Xiantao;  Zhu, Yuejie;  Wang, Chao;  Guan, Zhu;  Zhang, Lihe;  Yang, Zhenjun
收藏  |  浏览/下载:4/0  |  提交时间:2017/11/02
Thrombin Binding Aptamer  Alkylation  Antitumor  Selectivity  
Site-Specific PEGylated Adeno-Associated Viruses with Increased Serum Stability and Reduced Immunogenicity 期刊论文
MOLECULES, 2017, 卷号: 22, 期号: 7
作者:  Yao, Tianzhuo;  Zhou, Xueying;  Zhang, Chuanling;  Yu, Xiaojuan;  Tian, Zhenyu;  Zhang, Lihe;  Zhou, Demin
Adobe PDF(2420Kb)  |  收藏  |  浏览/下载:2/0  |  提交时间:2017/11/02
Adeno-associated Virus 2  Pegylation  Genetic Code Expansion  Selective Conjugation  
Isonucleotide incorporation into middle and terminal siRNA duplexes exhibits high gene silencing efficacy and nuclease resistance 期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2017, 卷号: 15, 期号: 24, 页码: 5161-5170
作者:  Ma, Yuan;  Liu, Shuang;  Wang, Yusi;  Zhao, Yuanhe;  Huang, Ye;  Zhong, Lijun;  Guan, Zhu;  Zhang, Lihe;  Yang, Zhenjun
收藏  |  浏览/下载:4/0  |  提交时间:2017/11/02
Facile preparation of a symmetric hexavalent oleanolic acid/per-O-methylated alpha-cyclodextrin conjugate with two conformations in solution and unambiguous NMR analysis 期刊论文
TETRAHEDRON, 2017, 卷号: 73, 期号: 17, 页码: 2512-2517
作者:  Tian, Zhenyu;  Meng, Kun;  Shi, Yanhong;  Zhang, Naixia;  Liu, Xuehui;  Jin, Hongwei;  Zhang, Yongmin;  Zhang, Lihe;  Zhou, Demin;  Xiao, Sulong
收藏  |  浏览/下载:2/0  |  提交时间:2017/12/21
Per-O-methylated alpha-cyclodextrin  Oleanolic acid  Click chemistry  Conformational exchange  NMR analysis